ArticleAnnals of biomedical engineering2013
Impact of ventilation frequency and parenchymal stiffness on flow and pressure distribution in a canine lung model.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Quantitative assessment of lung mechanical properties in ARDS using X-ray computed tomography.Intensive care medicine experimental · 2026Review
- Simulation of Central Airway Gas Flow Dynamics During Conventional and Multifrequency Ventilation.Journal of biomechanical engineering · 2025Article
- Design and Implementation of a Computer-Controlled Hybrid Oscillatory Ventilator.Journal of medical devices · 2025Article
- Gas transport mechanisms during high-frequency ventilation.Respiratory research · 2024Review
- Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.Journal of engineering and science in medical diagnostics and therapy · 2022Review
- Associating local strains to global pressure-volume mouse lung mechanics using digital image correlation.Physiological reports · 2022Article
- Regional Gas Transport During Conventional and Oscillatory Ventilation Assessed by Xenon-Enhanced Computed Tomography.Annals of biomedical engineering · 2021Article
- Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome.Current opinion in physiology · 2021Review
- High-Frequency Oscillatory Ventilation and Ventilator-Induced Lung Injury: Size Does Matter.Critical care medicine · 2020Article
- Quantifying Regional Lung Deformation Using Four-Dimensional Computed Tomography: A Comparison of Conventional and Oscillatory Ventilation.Frontiers in physiology · 2020Article
- Reactance and elastance as measures of small airways response to bronchodilator in asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Strain, strain rate, and mechanical power: An optimization comparison for oscillatory ventilation.International journal for numerical methods in biomedical engineering · 2019Article
- Computational Modeling of Primary Blast Lung Injury: Implications for Ventilator Management.Military medicine · 2019Article
- Targeted Versus Continuous Delivery of Volatile Anesthetics During Cholinergic Bronchoconstriction.Journal of engineering and science in medical diagnostics and therapy · 2018Article
- Parenchymal strain heterogeneity during oscillatory ventilation: why two frequencies are better than one.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Intratidal Overdistention and Derecruitment in the Injured Lung: A Simulation Study.IEEE transactions on bio-medical engineering · 2017Article
- Regional gas transport in the heterogeneous lung during oscillatory ventilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Multifrequency Oscillatory Ventilation in the Premature Lung: Effects on Gas Exchange, Mechanics, and Ventilation Distribution.Anesthesiology · 2015Article
- Volatile Anesthetics and the Treatment of Severe Bronchospasm: A Concept of Targeted Delivery.Drug discovery today. Disease models · 2015Article
- Pendelluft in the bronchial tree.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
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2 authors.
Funding
Abstract
To determine the impact of ventilation frequency, lung volume, and parenchymal stiffness on ventilation distribution, we developed an anatomically-based computational model of the canine lung. Each lobe of the model consists of an asymmetric branching airway network subtended by terminal, viscoelastic acinar units. The model allows for empiric dependencies of airway segment dimensions and parenchymal stiffness on transpulmonary pressure. We simulated the effects of lung volume and parenchymal recoil on global lung impedance and ventilation distribution from 0.1 to 100 Hz, with mean transpulmonary pressures from 5 to 25 cm H2O. With increasing lung volume, the distribution of acinar flows narrowed and became more synchronous for frequencies below resonance. At higher frequencies, large variations in acinar flow were observed. Maximum acinar flow occurred at first antiresonance frequency, where lung impedance achieved a local maximum. The distribution of acinar pressures became very heterogeneous and amplified relative to tracheal pressure at the resonant frequency. These data demonstrate the important interaction between frequency and lung tissue stiffness on the distribution of acinar flows and pressures. These simulations provide useful information for the optimization of frequency, lung volume, and mean airway pressure during conventional ventilation or high frequency oscillation (HFOV). Moreover our model indicates that an optimal HFOV bandwidth exists between the resonant and antiresonant frequencies, for which interregional gas mixing is maximized.
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