ArticlePediatric nephrology (Berlin, Germany)2013
Acute kidney injury and its association with in-hospital mortality among children with acute infections.
Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence of acute kidney injury-associated mortality in hospitalized children: a systematic review and meta-analysis.BMC nephrology · 2025Pooled it
- Long-term risk of chronic kidney disease and mortality in children after acute kidney injury: a systematic review.BMC nephrology · 2014Pooled it
- Trial
- AKI and Mortality in Children Hospitalized With Malnutrition.Kidney international reports · 2026Article
- Cystatin C for predicting acute kidney injury in critically ill children with bacterial infections: a retrospective cohort study.BMJ paediatrics open · 2026Article
- Article
- Identification of acute kidney injury in African children with severe malaria: a multinational individual participant data meta-analysis.Research square · 2025Article
- Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria.BMC nephrology · 2025Article
- Infections and Acute Kidney Injury: A Global Perspective.Seminars in nephrology · 2023Review
- Application of a physiologically based pharmacokinetic model in predicting captopril disposition in children with chronic kidney disease.Scientific reports · 2023Article
- Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria.The American journal of tropical medicine and hygiene · 2022Article
- Acute kidney injury in hospitalized children with sickle cell anemia.BMC nephrology · 2022Article
- Evaluating kidney function using a point-of-care creatinine test in Ugandan children with severe malaria: a prospective cohort study.BMC nephrology · 2021Article
- Age-specific risk factors of severe pneumonia among pediatric patients hospitalized with community-acquired pneumonia.Italian journal of pediatrics · 2021Article
- Chronic kidney disease impacts health-related quality of life of children in Uganda, East Africa.Pediatric nephrology (Berlin, Germany) · 2021Article
- Malaria-Associated Acute Kidney Injury in African Children: Prevalence, Pathophysiology, Impact, and Management Challenges.International journal of nephrology and renovascular disease · 2021Review
- Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study.BMC nephrology · 2020Article
- Incidence and epidemiology of acute kidney injury in a pediatric Malawian trauma cohort: a prospective observational study.BMC nephrology · 2020Observational
- Acute kidney injury among paediatric emergency room admissions in a tertiary hospital in South West Nigeria: a cohort study.Clinical kidney journal · 2019Article
- Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria.BMC medicine · 2019Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundWe investigated prevalence of acute kidney injury (AKI) at hospitalization and its association with in-hospital mortality among Ugandan children hospitalized with common acute infections, and predictors of mortality among AKI children.
methodsWe enrolled 2,055 children hospitalized with primary diagnoses of acute gastroenteritis, malaria, or pneumonia. Serum creatinine, albumin, electrolytes, hemoglobin, and urine protein were obtained on admission. Participants were assessed for AKI based on serum creatinine levels. Demographic and clinical data were obtained using a primary care provider survey and medical chart review. Logistic regression was used to determine predictors of in-hospital mortality.
resultsA total of 278 (13.5%) of children had AKI on admission; for 76.2%, AKI was stage 2 (98/278) or stage 3 (114/278) defined as serum creatinine >2- or 3-fold above normal upper limit for age, respectively. AKI prevalence was particularly high in gastroenteritis (28.6%) and underweight children (20.7%). Twenty-five percent of children with AKI died during hospitalization, compared to 9.9% with no AKI (adjusted odds ratio (aOR) 3.5 (95% CI, 2.2-5.5)). In-hospital mortality risk did not differ by AKI stage. Predictors of in-hospital mortality among AKI children included primary diagnosis of pneumonia, aOR 4.5 (95% CI, 1.8-11.2); proteinuria, aOR = 2.1 (95% CI, 1.0-4.9) and positive human immunodeficiency virus (HIV) status, aOR 5.0 (95% CI, 2.0-12.9).
conclusionsAmong children hospitalized with gastroenteritis, malaria, or pneumonia, AKI at admission was common and associated with high in-hospital mortality.
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