ArticleCellular & molecular immunology2013
Impaired NK cell antiviral cytokine response against influenza virus in small-for-gestational-age neonates.
Article in Cellular & molecular immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Trial
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- Review
- Epigenetic regulation of pediatric and neonatal immune responses.Pediatric research · 2022Review
- Infant Formula Based on Milk Fat Affects Immune Development in Both Normal Birthweight and Fetal Growth Restricted Neonatal Piglets.Nutrients · 2021Article
- Immune dysfunction in developmental programming of type 2 diabetes mellitus.Nature reviews. Endocrinology · 2021Review
- The role of NK cells in fighting the virus infection and sepsis.International journal of medical sciences · 2021Review
- Impaired Neonatal Immunity and Infection Resistance Following Fetal Growth Restriction in Preterm Pigs.Frontiers in immunology · 2020Article
- The Maternal-Fetal Interface in Small-for-Gestational-Age Pregnancies Is Associated With a Reduced Quantity of Human Decidual NK Cells With Weaker Functional Ability.Frontiers in cell and developmental biology · 2020Article
- Why are preterm newborns at increased risk of infection?Archives of disease in childhood. Fetal and neonatal edition · 2018Review
- Avian influenza virus directly infects human natural killer cells and inhibits cell activity.Virologica Sinica · 2017Article
- Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis from Sepsis in Early Stage of the Disease.Journal of immunology research · 2016Article
- Influenza A Virus Infection, Innate Immunity, and Childhood.JAMA pediatrics · 2015Review
- Underweight full-term Indian neonates show differences in umbilical cord blood leukocyte phenotype: a cross-sectional study.PloS one · 2015Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neonates, particularly small-for-gestational-age (SGA) ones, are susceptible to various microbial infections. Natural killer (NK) cells are critical components of host innate immunity system and the main source of the inflammatory cytokines, which provide critical protection during the early phase of viral infections before the development of an appropriate adaptive immune response. However, little is known about the antiviral effects of NK cells in neonates especially the SGA population. Herein, a prospective descriptive study was performed to determine the differences of NK cell immunity among adults, appropriate-for gestational-age (AGA) and SGA neonates. Adults have much higher NK cell number in peripheral blood than that in cord blood from neonates. In response to influenza virus stimulation, neonatal NK cells, especially SGA baby cells, expressed significantly lower antiviral cytokines including perforin, interferon (IFN)-γ and tumor-necrosis factor (TNF)-α responses than adult NK cells. In addition, the antiviral cytokine responses of NK cells were positively correlated with neonatal birth weight. Our data suggested that the depressed antiviral activity and less frequency of NK cells are likely to be responsible for the high susceptibility to microbial infection in neonates, at least in part. Improving the function of innate immunity may provide a new way to defend virus infection.
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