ArticleNature neuroscience2013
Fear-enhancing effects of septal oxytocin receptors.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
94 citing papers in PubMed, 214 citations in OpenAlex.
- Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals.Social cognitive and affective neuroscience · 2016Trial
- Oxytocin facilitates the sensation of social stress.Human brain mapping · 2014Trial
- Complexity of oxytocin׳s effects in a chronic cocaine dependent population.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Trial
- Oxytocin enhances brain reward system responses in men viewing the face of their female partner.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Oxytocin in social conflict.Nature reviews. Endocrinology · 2026Article
- Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment.Science advances · 2026Article
- SARS-CoV-2 Spike Protein S1 Subunit Induces Neuroinflammation Via Microglial Kv1.3 Channel.Biological psychiatry global open science · 2026Article
- Oxytocin receptors mediate social selectivity in prairie vole peer relationships.Current biology : CB · 2025Article
- Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025Review
- Group Social Dynamics in a Seminatural Setup Reflect the Adaptive Value of Aggression in Male Mice.Biological psychiatry global open science · 2025Article
- Input-specific properties of excitatory synapses on oxytocin receptor-expressing neurons in the lateral septum.Journal of neurophysiology · 2024Article
- Astrocytic inhibition of lateral septal neurons promotes diverse stress responses.Nature communications · 2024Article
- Social interaction-induced fear memory reduction: exploring the influence of dopamine and oxytocin receptors on memory updating.Translational psychiatry · 2024Article
- Social buffering in rats reduces fear by oxytocin triggering sustained changes in central amygdala neuronal activity.Nature communications · 2024Article
- Article
- CD38 genetic variation is associated with increased personal distress to an emotional stimulus.Scientific reports · 2024Article
- Detection, processing and reinforcement of social cues: regulation by the oxytocin system.Nature reviews. Neuroscience · 2023Review
- Chronic oxytocin-driven alternative splicing of Crfr2α induces anxiety.Molecular psychiatry · 2023Article
- Monitoring oxytocin signaling in the brain: More than a love story.Comprehensive psychoneuroendocrinology · 2023Review
- Hyperactivity of the Lateral Septum Leads to Hypersensitivity in Susceptible Mice.Neuroscience bulletin · 2023Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic, prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently emerged. Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of Oxtr. These effects emerge after social defeat and require Oxtr specifically coupled to the extracellular signal-regulated protein kinase pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.