Trial reportHeart (British Cardiac Society)2013
MRI-measured regression of carotid atherosclerosis induced by statins with and without niacin in a randomised controlled trial: the NIA plaque study.
Trial report in Heart (British Cardiac Society), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01212900. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The RIGHT Study: Risk Stratification With Image Guidance of HMG Coa Reductase Inhibitor Therapy
Open the trial in the graphWho cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Assessment of Therapeutic Response to Statin Therapy in Patients With Intracranial or Extracranial Carotid Atherosclerosis by Vessel Wall MRI: A Systematic Review and Updated Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.JAMA network open · 2019 · on this mapPooled it
- Niacin for primary and secondary prevention of cardiovascular events.The Cochrane database of systematic reviews · 2017 · on this mapPooled it
- Niacin therapy and the risk of new-onset diabetes: a meta-analysis of randomised controlled trials.Heart (British Cardiac Society) · 2016 · on this mapPooled it
- Magnetic Resonance Imaging of Intraplaque Hemorrhage and Plaque Lipid Content With Continued Lipid-Lowering Therapy: Results of a Magnetic Resonance Imaging Substudy in AIM-HIGH.Circulation. Cardiovascular imaging · 2022Trial
- Diagnostic Performance of General Practitioners in Carotid Plaque Detection Using AI-Enhanced Point-of-Care Ultrasound After Systematic Training.Annals of family medicine · 2026Article
- Ellagic Acid and Its Nanoparticles Mitigate Atherosclerosis by Elevating Low-Density Lipoprotein Receptor Levels Through Targeting of the Epidermal Growth Factor Receptor.FASEB bioAdvances · 2025Article
- Progression rate of radiation-induced carotid stenosis in head and neck cancer survivors after statin treatment: a retrospective cohort study.Journal of neurology · 2024Article
- The impact of lipid-lowering medications on coronary artery plaque characteristics.American journal of preventive cardiology · 2021Article
- Atherosclerosis: Making a U Turn.Annual review of medicine · 2020Review
- An Ultrasound Model to Predict the Short-Term Effects of Endovascular Stent Placement in the Treatment of Carotid Artery Stenosis.Frontiers in cardiovascular medicine · 2020Article
- Imaging as a surrogate marker of drug efficacy in cardiovascular disease.Heart (British Cardiac Society) · 2019Article
- Obesity Is Associated With Progression of Atherosclerosis During Statin Treatment.Journal of the American Heart Association · 2016Article
- Imaging Atherosclerosis.Circulation research · 2016Review
- Noninvasive Imaging of Atherosclerotic Plaque Progression: Status of Coronary Computed Tomography Angiography.Circulation. Cardiovascular imaging · 2015Review
- Lowering triglycerides to modify cardiovascular risk: will icosapent deliver?Vascular health and risk management · 2015Review
- Assessment of atherosclerosis in chronic granulomatous disease.Circulation · 2014Observational
- Atherosclerosis: Addition of niacin to optimal statin therapy does not affect plaque regression.Nature reviews. Cardiology · 2013Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the benefit of niacin in addition to statin therapy on plaque regression among older individuals with established atherosclerosis.
designRandomised, controlled, double-blind clinical trial.
settingUniversity outpatient center. PATIENTS: 145 patients older than 65 years, half of them older than 75 years of age, with established atherosclerosis were enrolled.
interventionsParticipants received either extended release niacin (1500 mg daily) or placebo in addition to statin therapy to reach their National Cholesterol Education Program-defined low density lipoprotein (LDL) cholesterol target.
main outcome measuresThe primary endpoint was reduction in the wall volume of the internal carotid artery (ICA) measured by MRI.
resultsAfter 18 months, high density lipoprotein cholesterol was higher with statins plus niacin compared with statins alone (1.6 ± 0.4 vs 1.4 ± 0.4 mmol/L p<0.001). Both groups had significant decreases in the main outcome measure of ICA wall volume, which regressed at 0.5%/month (SEM 0.2, p=0.004) in the statins plus placebo group and at 0.7%/month in the statins plus niacin group (SEM 0.2, p<0.001). There was no difference in the rate of regression between groups (p=0.49).
conclusionsTreatment with statin therapy to presently recommended LDL levels, with or without niacin, resulted in significant atherosclerosis reduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.