ArticleToxicological sciences : an official journal of the Society of Toxicology2013
Short-term exposure to ozone does not impair vascular function or affect heart rate variability in healthy young men.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Effects of controlled, acute exposure to air pollutants on heart rate variability in humans: a meta-regression and methodological recommendations.BMC public health · 2026Pooled it
- Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Fish oil blunts lung function decrements induced by acute exposure to ozone in young healthy adults: A randomized trial.Environment international · 2022Trial
- Trial
- Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects.American journal of physiology. Heart and circulatory physiology · 2015Trial
- Cardiovascular effects of ozone in healthy subjects with and without deletion of glutathione-S-transferase M1.Inhalation toxicology · 2015Trial
- Exposure to traffic-related air pollution during physical activity and acute changes in blood pressure, autonomic and micro-vascular function in women: a cross-over study.Particle and fibre toxicology · 2014Trial
- Short-term ozone exposure on stroke mortality and mitigation by greenness in rural and urban areas of Shandong Province, China.BMC public health · 2024Article
- The cardiovascular effects of air pollution: Prevention and reversal by pharmacological agents.Pharmacology & therapeutics · 2022Review
- Time series analysis of short-term effects of particulate matter pollution on the circulatory system disease mortality risk in Lishui District, China.Environmental science and pollution research international · 2022Article
- Ambient air pollution exposure and radiographic pulmonary vascular volumes.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children: A Repeated-Measure Panel Study.Innovation (Cambridge (Mass.)) · 2021Article
- Air Pollution-Induced Autonomic Modulation.Physiology (Bethesda, Md.) · 2020Review
- Oxidative stress and the cardiovascular effects of air pollution.Free radical biology & medicine · 2020Review
- Multicenter Ozone Study in oldEr Subjects (MOSES): Part 2. Effects of Personal and Ambient Concentrations of Ozone and Other Pollutants on Cardiovascular and Pulmonary Function.Research report (Health Effects Institute) · 2020Article
- Ambient Ozone Pollution and Daily Mortality: A Nationwide Study in 272 Chinese Cities.Environmental health perspectives · 2017Article
- TRPA1 mediates changes in heart rate variability and cardiac mechanical function in mice exposed to acrolein.Toxicology and applied pharmacology · 2017Article
- Multicenter Ozone Study in oldEr Subjects (MOSES): Part 1. Effects of Exposure to Low Concentrations of Ozone on Respiratory and Cardiovascular Outcomes.Research report (Health Effects Institute) · 2017Article
- Long-Term Exposure to NO2 and Ozone and Hypertension Incidence in the Black Women's Health Study.American journal of hypertension · 2017Article
- Linking physiological parameters to perturbations in the human exposome: Environmental exposures modify blood pressure and lung function via inflammatory cytokine pathway.Journal of toxicology and environmental health. Part A · 2017Article
Corrections and comments
- Commented on by
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Air pollution exposure is associated with cardiovascular morbidity and mortality, yet the role of individual pollutants remains unclear. In particular, there is uncertainty regarding the acute effect of ozone exposure on cardiovascular disease. In these studies, we aimed to determine the effect of ozone exposure on vascular function, fibrinolysis, and the autonomic regulation of the heart. Thirty-six healthy men were exposed to ozone (300 ppb) and filtered air for 75min on two occasions in randomized double-blind crossover studies. Bilateral forearm blood flow (FBF) was measured using forearm venous occlusion plethysmography before and during intra-arterial infusions of vasodilators 2-4 and 6-8h after each exposure. Heart rhythm and heart rate variability (HRV) were monitored during and 24h after exposure. Compared with filtered air, ozone exposure did not alter heart rate, blood pressure, or resting FBF at either 2 or 6h. There was a dose-dependent increase in FBF with all vasodilators that was similar after both exposures at 2-4h. Ozone exposure did not impair vasomotor or fibrinolytic function at 6-8h but rather increased vasodilatation to acetylcholine (p = .015) and sodium nitroprusside (p = .005). Ozone did not affect measures of HRV during or after the exposure. Our findings do not support a direct rapid effect of ozone on vascular function or cardiac autonomic control although we cannot exclude an effect of chronic exposure or an interaction between ozone and alternative air pollutants that may be responsible for the adverse cardiovascular health effects attributed to ozone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.