ArticleApplied and environmental microbiology2013
Utilization of heme as an iron source by marine Alphaproteobacteria in the Roseobacter clade.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Contrasting microbial iron metabolism in sediments from oxic and hypoxic estuaries.Frontiers in microbiology · 2026Article
- Iron limitation of heterotrophic bacteria in the California Current System tracks relative availability of organic carbon and iron.The ISME journal · 2024Article
- Algal p-coumaric acid induces oxidative stress and siderophore biosynthesis in the bacterial symbiont Phaeobacter inhibens.Cell chemical biology · 2022Article
- Signs of biofilm formation in the genome ofSaudi journal of biological sciences · 2021Article
- Characterization of the Fe metalloproteome of a ubiquitous marine heterotroph, Pseudoalteromonas (BB2-AT2): multiple bacterioferritin copies enable significant Fe storage.Metallomics : integrated biometal science · 2020Article
- Transcriptomic Study of Substrate-Specific Transport Mechanisms for Iron and Carbon in the Marine Copiotroph Alteromonas macleodii.mSystems · 2020Article
- Heme b distributions through the Atlantic Ocean: evidence for "anemic" phytoplankton populations.Scientific reports · 2020Article
- Regulation of the Phytoplankton HemeFrontiers in microbiology · 2019Article
- Phenomics and Genomics Reveal Adaptation ofFrontiers in microbiology · 2019Article
- Trajectories and Drivers of Genome Evolution in Surface-Associated Marine Phaeobacter.Genome biology and evolution · 2017Article
- TonB-Dependent Heme/Hemoglobin Utilization by Caulobacter crescentus HutA.Journal of bacteriology · 2017Article
- Abundance of the iron containing biomolecule, heme b, during the progression of a spring phytoplankton bloom in a mesocosm experiment.PloS one · 2017Article
- Trace Metal Acquisition by Marine Heterotrophic Bacterioplankton with Contrasting Trophic Strategies.Applied and environmental microbiology · 2016Article
- Quantifying Integrated Proteomic Responses to Iron Stress in the Globally Important Marine Diazotroph Trichodesmium.PloS one · 2015Article
- The LysR-type transcription factor HbrL is a global regulator of iron homeostasis and porphyrin synthesis in Rhodobacter capsulatus.Molecular microbiology · 2013Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bioavailability and utilization of porphyrin-bound iron, specifically heme, by marine microorganisms have rarely been examined. This study used Ruegeria sp. strain TrichCH4B as a model organism to study heme acquisition by a member of the Roseobacter clade. Analogs of known heme transporter proteins were found within the Ruegeria sp. TrichCH4B genome. The identified heme uptake and utilization system appears to be functional, as the heme genes were upregulated under iron stress, the bacterium could grow on ferric-porphyrin complexes as the sole iron source, and internalization of (55) Fe from ferric protoporphyrin IX was observed. The potential ability to utilize heme in the Roseobacter clade appears to be common, as half of the isolates in the RoseoBase database were found to have a complete heme uptake system. A degenerate primer set was designed and successfully used to identify the putative heme oxygenase gene (hmus) in the roseobacter heme uptake system from diverse nonenriched marine environments. This study found that members of the Roseobacter clade are capable of utilizing heme as an iron source and that this capability may be present in all types of marine environments. The results of this study add a new perspective to the current picture of iron cycling in marine systems, whereby relatively refractory intracellular pools of heme-bound iron may be taken up quickly and directly reincorporated into living bacteria without previous degradation or the necessity of a siderophore intermediate.
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