ReviewCurrent opinion in hematology2013
The use of microfluidics in hemostasis: clinical diagnostics and biomimetic models of vascular injury.
Review in Current opinion in hematology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Dimensional analysis and scaling relevant to flow models of thrombus formation: communication from the SSC of the ISTH.Journal of thrombosis and haemostasis : JTH · 2016Guideline
- Automated Imaging and Analysis of Platelet, Coagulation and Fibrinolysis Activities Using a Novel Flow Chip-Based System at Physiological Temperature.Micromachines · 2025Article
- Injury-on-a-chip for modelling microvascular trauma-induced coagulation.Lab on a chip · 2025Article
- A single-particle mechanofluorescent sensor.Nature communications · 2024Article
- Fluid flow to mimic organ function in 3DAPL bioengineering · 2023Review
- Automated analysis of mitochondrial dimensions in mesenchymal stem cells: Current methods and future perspectives.Heliyon · 2023Review
- Microfluidics in Haemostasis: A Review.Molecules (Basel, Switzerland) · 2020Review
- Platelet Adhesion and Thrombus Formation in Microchannels: The Effect of Assay-Dependent Variables.International journal of molecular sciences · 2020Article
- Adsorption and Absorption of Collagen Peptides to Polydimethlysiloxane and Its Influence on Platelet Adhesion Flow Assays.Micromachines · 2020Article
- Hemostasis-On-a-Chip: Impedance Spectroscopy Meets Microfluidics for Hemostasis Evaluation.Micromachines · 2019Article
- The effect of platelet storage temperature on haemostatic, immune, and endothelial function: potential for personalised medicine.Blood transfusion = Trasfusione del sangue · 2019Review
- A microengineered vascularized bleeding model that integrates the principal components of hemostasis.Nature communications · 2018Article
- Flow chamber and microfluidic approaches for measuring thrombus formation in genetic bleeding disorders.Platelets · 2017Review
- Article
- Rapid antibiotic sensitivity testing in microwell arrays.Technology · 2017Article
- A microfluidic model of hemostasis sensitive to platelet function and coagulation.Cellular and molecular bioengineering · 2017Article
- Blood flow and mass transfer regulation of coagulation.Blood reviews · 2016Review
- Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium.Biomedical microdevices · 2016Article
- Nanomedicines for Endothelial Disorders.Nano today · 2015Article
- Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis.Thrombosis research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThis article reviews the application of microfluidic technologies in hemostasis. The emphasis is on promising developments in devices for clinical applications and novel approaches to modeling complex hemodynamics. RECENT
findingsMicrofluidics combined with micropatterning of prothrombotic substrates provides devices for measuring platelet function and coagulation with low blood volumes (∼100 μl) over a wide range of shear stresses. This technology has been applied to the diagnosis of bleeding and thrombotic disorders, as well as to dosing and monitoring of anticoagulation and antiplatelet agents. Microfluidic devices that mimic vascular geometries such as bifurcations, stenosis, and complex interconnected networks yield complex flow fields that have revealed new mechanisms of platelet adhesion and aggregation. Applying techniques from tissue engineering by endothelializing these networks is beginning to close the gap between in-vitro and in-vivo models of vascular injury. SUMMARY: Microfluidic technology enables researchers to create in-vitro models of vascular disease with unprecedented control of the biochemical and biophysical conditions. Two promising directions are flow-dependent clinical assays and biomimetic vascular networks. These approaches are particularly well suited for modeling the microvasculature. However, caution should be used when extrapolating results from microfluidic channels to the pathophysiology of thrombosis in large arteries and veins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.