ArticleCancer prevention research (Philadelphia, Pa.)2013
Plasma adiponectin and soluble leptin receptor and risk of colorectal cancer: a prospective study.
Article in Cancer prevention research (Philadelphia, Pa.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- The role of Adiponectin and Leptin in Colorectal Cancer and Adenoma: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Systemic adiponectin levels in colorectal cancer and adenoma: a systematic review and meta-analysis.International journal of obesity (2005) · 2023Pooled it
- Circulating adiponectin levels in various malignancies: an updated meta-analysis of 107 studies.Oncotarget · 2016Pooled it
- Association between obesity-related adipokines and colorectal cancer: a case-control study and meta-analysis.World journal of gastroenterology · 2014Pooled it
- Association of Adiponectin and Vitamin D With Tumor Infiltrating Lymphocytes and Survival in Stage III Colon Cancer.JNCI cancer spectrum · 2021Trial
- Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals.The American journal of clinical nutrition · 2019Trial
- Inflammatory biomarkers, aspirin, and risk of colorectal cancer: Findings from the physicians' health study.Cancer epidemiology · 2016Trial
- Remodeling the Immune Landscape: How Obesity-Induced SASPs Create a Pro-Tumorigenic Niche.Current obesity reports · 2026Review
- Body Roundness Index and Incident Colorectal Cancer Risk: A Nationwide Population-Based Cohort Study.Cancers · 2026Article
- Adiposity and cancer: epidemiology, mechanisms and future perspectives.Nature metabolism · 2026Review
- Article
- Metabolomic signatures of inflammation and metabolic dysregulation in relation to colorectal cancer risk.Journal of the National Cancer Institute · 2024Article
- Sex-Specific Associations between Adiponectin and Leptin Signaling and Pancreatic Cancer Survival.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Fructose consumption from different food sources and cardiometabolic biomarkers: cross-sectional associations in US men and women.The American journal of clinical nutrition · 2023Article
- Impacts of long-term ambient particulate matter and gaseous pollutants on circulating biomarkers of inflammation in male and female health professionals.Environmental research · 2022Article
- Effects of Sex and Obesity onInternational journal of molecular sciences · 2022Article
- Lipid-Lowering Drug Use and Cancer Incidence and Mortality in the ARIC Study.JNCI cancer spectrum · 2021Article
- Association between pre-diagnostic circulating adipokines and colorectal cancer and adenoma in the CLUE II cohort.Cancer causes & control : CCC · 2021Article
- Circulating adipokine concentrations and risk of five obesity-related cancers: A Mendelian randomization study.International journal of cancer · 2021Article
- Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Adipokines are adipocyte-secreted hormones that may mediate the etiologic link between obesity and colorectal cancer; however, the evidence from large prospective studies is limited. We prospectively evaluated the association of plasma adiponectin and soluble leptin receptor (sOB-R) with colorectal cancer risk within the Nurses' Health Study (1990-2008) and the Health Professionals Follow-up Study (1994-2008) among 616 incident colorectal cancer cases and 1,205 controls selected using risk-set sampling and matched on age and date of blood draw. In unconditional logistic regression with adjustment for matching factors and multiple risk factors, plasma adiponectin was significantly associated with reduced risk of colorectal cancer among men, but not among women. Compared with men in the lowest quartile of adiponectin, men in the highest quartile had a relative risk (RR) for colorectal cancer of 0.55 [95% confidence interval (CI), 0.35-0.86; Ptrend = 0.02]. The corresponding RR in women was 0.96 (95% CI, 0.67-1.39; Ptrend = 0.74). Plasma sOB-R was not associated with overall colorectal cancer risk in either men or women. A significant heterogeneity was noted in the association between sOB-R and colorectal cancer by subsite in women (Pheterogeneity = 0.004); sOB-R was significantly associated with increased risk of rectal cancer but not colon cancer. These findings support a role for adiponectin in colorectal carcinogenesis in men. Further studies are warranted to confirm these associations and elucidate potential underlying mechanisms.
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