ArticlePharmacology, biochemistry, and behavior2013
Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice.
Article in Pharmacology, biochemistry, and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Behavioural, Neural and Molecular Effects Underlying Caffeine's Addictive Properties.Addiction biology · 2025Article
- Neurochemical and Behavioral Consequences of Ethanol and/or Caffeine Exposure: Effects in Zebrafish and Rodents.Current neuropharmacology · 2022Review
- The implications of alcohol mixed with energy drinks from medical and socio-legal standpoints.Frontiers in behavioral neuroscience · 2022Review
- Effect of caffeine on alcohol drinking in mice.Alcohol (Fayetteville, N.Y.) · 2021Article
- Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference.Addiction biology · 2020Article
- Rewarding and aversive doses of caffeine alter activity but not conditioned place preference induced by ethanol in DBA/2J mice.Pharmacology, biochemistry, and behavior · 2019Article
- Glyoxalase 1 (GLO1) Inhibition or Genetic Overexpression Does Not Alter Ethanol's Locomotor Effects: Implications for GLO1 as a Therapeutic Target in Alcohol Use Disorders.Alcoholism, clinical and experimental research · 2018Article
- Desire to Drink Alcohol is Enhanced with High Caffeine Energy Drink Mixers.Alcoholism, clinical and experimental research · 2016Article
- Concomitant Caffeine Increases Binge Consumption of Ethanol in Adolescent and Adult Mice, But Produces Additive Motor Stimulation Only in Adolescent Animals.Alcoholism, clinical and experimental research · 2016Article
- Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.Psychopharmacology · 2016Review
- Unique Behavioral and Neurochemical Effects Induced by Repeated Adolescent Consumption of Caffeine-Mixed Alcohol in C57BL/6 Mice.PloS one · 2016Article
- Energy Drink Administration in Combination with Alcohol Causes an Inflammatory Response and Oxidative Stress in the Hippocampus and Temporal Cortex of Rats.Oxidative medicine and cellular longevity · 2016Article
- Sensitization and Tolerance Following Repeated Exposure to Caffeine and Alcohol in Mice.Alcoholism, clinical and experimental research · 2015Article
- Can energy drinks increase the desire for more alcohol?Advances in nutrition (Bethesda, Md.) · 2015Review
- Energy drinks mixed with alcohol: what are the risks?Nutrition reviews · 2014Review
- "Wired," yet intoxicated: modeling binge caffeine and alcohol co-consumption in the mouse.Alcoholism, clinical and experimental research · 2014Article
- Inhibition of urokinase plasminogen activator "uPA" activity alters ethanol consumption and conditioned place preference in mice.Drug design, development and therapy · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75 g/kg ethanol and 3 mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25 g/kg) and 2 two doses of caffeine (3 and 15 mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75 g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.