ReviewFrontiers in neuroendocrinology2013
Sex differences and hormonal modulation of deep tissue pain.
Review in Frontiers in neuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 84 citations in OpenAlex.
- Estrogen-Mediated Neural Mechanisms of Sex Differences in Burning Mouth Syndrome.Neurology international · 2025Article
- Article
- The adjunct role of pharmacotherapy in multimodal treatment of paediatric functional neurological disorder.Frontiers in psychiatry · 2025Article
- Degenerative and regenerative peripheral processes are associated with persistent painful chemotherapy-induced neuropathies in males and females.Scientific reports · 2024Article
- Characterization of Fragile X Mental Retardation Protein expression in human nociceptors and their axonal projections to the spinal dorsal horn.The Journal of comparative neurology · 2023Article
- Gender specific somatic symptom burden and mortality risk in the general population.Scientific reports · 2022Article
- Oxycodone/naloxone versus tapentadol in real-world chronic non-cancer pain management: an observational and pharmacogenetic study.Scientific reports · 2022Observational
- Article
- Sex-dependent pain trajectories induced by prolactin require an inflammatory response for pain resolution.Brain, behavior, and immunity · 2022Article
- Nociceptor Overexpression of NaThe journal of pain · 2021Article
- Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis.Rheumatic diseases clinics of North America · 2021Review
- Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice.Scientific reports · 2021Article
- Mechanisms Underlying Lumbopelvic Pain During Pregnancy: A Proposed Model.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Sex differences in neuro(auto)immunity and chronic sciatic nerve pain.Biology of sex differences · 2020Review
- Transcriptomic sex differences in sensory neuronal populations of mice.Scientific reports · 2020Article
- Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Efficacy of Contrast Transthoracic Echocardiography and Contrast Transcranial Doppler for the Detection of Patent Foramen Ovale Related to Cryptogenic Stroke.BioMed research international · 2020Article
- Prolactin Regulates Pain Responses via a Female-Selective Nociceptor-Specific Mechanism.iScience · 2019Article
- Abdominal pain during the menopause transition and early postmenopause: observations from the Seattle Midlife Women's Health Study.Women's midlife health · 2019Article
- Diffuse noxious inhibitory controls and brain networks are modulated in a testosterone-dependent manner in Sprague Dawley rats.Behavioural brain research · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Women disproportionately suffer from many deep tissue pain conditions. Experimental studies show that women have lower pain thresholds, higher pain ratings and less tolerance to a range of painful stimuli. Most clinical and epidemiological reports suggest female gonadal hormones modulate pain for some, but not all, conditions. Similarly, animal studies support greater nociceptive sensitivity in females in many deep tissue pain models. Gonadal hormones modulate responses in primary afferents, dorsal horn neurons and supraspinal sites, but the direction of modulation is variable. This review will examine sex differences in deep tissue pain in humans and animals focusing on the role of gonadal hormones (mainly estradiol) as an underlying component of the modulation of pain sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.