ArticleDevelopmental biology2013
Postembryonic lineages of the Drosophila brain: II. Identification of lineage projection patterns based on MARCM clones.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.Cell genomics · 2026Article
- Hierarchical diversification of instinctual behavior neurons by lineage, birth order, and sex.bioRxiv : the preprint server for biology · 2025Article
- Stem cell-specific ecdysone signaling regulates the development of dorsal fan-shaped body neurons and sleep homeostasis.Current biology : CB · 2024Article
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- Stem cell-specific ecdysone signaling regulates the development and function of abioRxiv : the preprint server for biology · 2023Article
- Lineages to circuits: the developmental and evolutionary architecture of information channels into the central complex.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- Asymmetric activity of NetrinB controls laterality of the Drosophila brain.Nature communications · 2023Article
- The role of cell lineage in the development of neuronal circuitry and function.Developmental biology · 2021Review
- Article
- Sequence heterochrony led to a gain of functionality in an immature stage of the central complex: A fly-beetle insight.PLoS biology · 2020Article
- Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain.Current biology : CB · 2020Article
- Article
- Article
- Developmentally Arrested Precursors of Pontine Neurons Establish an Embryonic Blueprint of the Drosophila Central Complex.Current biology : CB · 2019Article
- Structure and development of the subesophageal zone of the Drosophila brain. II. Sensory compartments.The Journal of comparative neurology · 2018Article
- Structure and development of the subesophageal zone of the Drosophila brain. I. Segmental architecture, compartmentalization, and lineage anatomy.The Journal of comparative neurology · 2018Article
- Neuronal Constituents and Putative Interactions Within theFrontiers in neural circuits · 2018Article
- Development of the anterior visual input pathway to the Drosophila central complex.The Journal of comparative neurology · 2017Article
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6 authors at 1 institution in 1 country.
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Abstract
The Drosophila central brain is largely composed of lineages, units of sibling neurons derived from a single progenitor cell or neuroblast. During the early embryonic period, neuroblasts generate the primary neurons that constitute the larval brain. Neuroblasts reactivate in the larva, adding to their lineages a large number of secondary neurons which, according to previous studies in which selected lineages were labeled by stably expressed markers, differentiate during metamorphosis, sending terminal axonal and dendritic branches into defined volumes of the brain neuropil. We call the overall projection pattern of neurons forming a given lineage the "projection envelope" of that lineage. By inducing MARCM clones at the early larval stage, we labeled the secondary progeny of each neuroblast. For the supraesophageal ganglion excluding mushroom body (the part of the brain investigated in the present work) we obtained 81 different types of clones. Based on the trajectory of their secondary axon tracts (described in the accompanying paper, Lovick et al., 2013), we assigned these clones to specific lineages defined in the larva. Since a labeled clone reveals all aspects (cell bodies, axon tracts, terminal arborization) of a lineage, we were able to describe projection envelopes for all secondary lineages of the supraesophageal ganglion. This work provides a framework by which the secondary neurons (forming the vast majority of adult brain neurons) can be assigned to genetically and developmentally defined groups. It also represents a step towards the goal to establish, for each lineage, the link between its mature anatomical and functional phenotype, and the genetic make-up of the neuroblast it descends from.
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