ArticlePain2013
Offset analgesia is reduced in older adults.
Article in Pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 78 citations in OpenAlex.
- Perception of first and second pain during offset analgesia.Experimental brain research · 2025Trial
- Trial
- Trial
- Chronic Pain in Older Adults: Risk Factors and Prevention.Life (Basel, Switzerland) · 2026Review
- BDKRB2 upregulation by dystrophic microglia drives pain hypersensitivity in aged mice.Acta pharmacologica Sinica · 2026Article
- Article
- Prognostic Scoring Model for the Transition From Acute to Chronic Non-specific Low Back Pain in Primary Health Care Units in Indonesia.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Effects of Repetitive Transcranial Magnetic Stimulation Applied over the Primary Motor Cortex on the Offset Analgesia Phenomenon.Life (Basel, Switzerland) · 2025Article
- Repetitive Transcranial Magnetic Stimulation of the Human Motor Cortex Modulates Processing of Heat Pain Sensation as Assessed by the Offset Analgesia Paradigm.Journal of clinical medicine · 2023Article
- Functional connectivity modulations during offset analgesia in chronic pain patients: an fMRI study.Brain imaging and behavior · 2022Article
- Family History of Alcohol Use Disorder as a Predictor of Endogenous Pain Modulation Among Moderate to Heavy Drinkers.The journal of pain · 2022Article
- Chronic Pain in the Elderly: Mechanisms and Distinctive Features.Biomolecules · 2021Review
- Multidimensional investigation of chronic pain experience and physical functioning following hip fracture surgery: clinical implications.British journal of pain · 2020Article
- Hyperalgesia and Reduced Offset Analgesia During Spinal Anesthesia.Journal of pain research · 2020Article
- Article
- No temporal contrast enhancement of simple decreases in noxious heat.Journal of neurophysiology · 2019Article
- Sex Differences in Associations of Cognitive Function with Perceptions of Pain in Older Adults.Journal of Alzheimer's disease : JAD · 2019Article
- The impact of multisite pain on functional outcomes in older adults: biopsychosocial considerations.Journal of pain research · 2019Review
- Loss of Temporal Inhibition of Nociceptive Information Is Associated With Aging and Bodily Pain.The journal of pain · 2017Article
- Low back pain in older adults: risk factors, management options and future directions.Scoliosis and spinal disorders · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies indicate that aging is associated with dysfunctional changes in pain modulatory capacity, potentially contributing to increased incidence of pain in older adults. However, age-related changes in offset analgesia (offset), a form of temporal pain inhibition, remain poorly characterized. The purpose of this study was to investigate age differences in offset analgesia of heat pain in healthy younger and older adults. To explore the peripheral mechanisms underlying offset, an additional aim of the study was to test offset at 2 anatomical sites with known differences in nociceptor innervation. A total of 25 younger adults and 20 older adults completed 6 offset trials in which the experimental heat stimulus was presented to the volar forearm and glabrous skin of the palm. Each trial consisted of 3 continuous phases: an initial 15-second painful stimulus (T1), a slight increase in temperature from T1 for 5 seconds (T2), and a slight decrease back to the initial testing temperature for 10 seconds (T3). During each trial, subjects rated pain intensity continuously using an electronic visual analogue scale (0-100). Older adults demonstrated reduced offset compared to younger adults when tested on the volar forearm. Interestingly, offset analgesia was nonexistent on the palm for all subjects. The reduced offset found in older adults may reflect an age-related decline in endogenous inhibitory systems. However, although the exact mechanisms underlying offset remain unknown, the absence of offset at the palm suggests that peripheral mechanisms may be involved in initiating this phenomenon.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.