ArticleJournal of the American College of Cardiology2013
Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis).
Article in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02517944 (MYOCARDIAL SILENT INFARCTIONS AND FIBROSIS IN FAMILIAL HYPERCHOLESTEROLEMIA), which is not on this map. Cited by 194 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Myocardial silent infarctions and fibrosis in familial hypercholesterolemia
Who cites it
194 citing papers in PubMed, 2 syntheses or guidelines pooled it, 339 citations in OpenAlex.
- Sex Matters: A Comprehensive Comparison of Female and Male Hearts.Frontiers in physiology · 2022Pooled it
- Native T1 and Extracellular Volume Measurements by Cardiac MRI in Healthy Adults: A Meta-Analysis.Radiology · 2019Pooled it
- Resistance training improves cardiac function in older women: a randomized controlled trial.GeroScience · 2025Trial
- Impact of Diabetes Mellitus on Ventricular Structure, Arterial Stiffness, and Pulsatile Hemodynamics in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2019Trial
- Hypertrophy Regression With N-Acetylcysteine in Hypertrophic Cardiomyopathy (HALT-HCM): A Randomized, Placebo-Controlled, Double-Blind Pilot Study.Circulation research · 2018Trial
- Isosorbide Dinitrate, With or Without Hydralazine, Does Not Reduce Wave Reflections, Left Ventricular Hypertrophy, or Myocardial Fibrosis in Patients With Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2017Trial
- Differential cardiac remodelling: patterns of cardiomyocyte morphometry in multiple patient conditions.Cardiovascular research · 2026Article
- Article
- Native myocardial T1 reference values in a tunisian cohort using MOLLI and SMART1Map.Scientific reports · 2026Article
- Association between particulate matter air pollution and subclinical myocardial fibrosis in structurally normal hearts: a CMR-based study.European heart journal. Cardiovascular Imaging · 2026Article
- Reference ranges for myocardial native T1, T2, and extracellular volume at 5.0T cardiac magnetic resonance imaging in healthy adults.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026Article
- Detecting early structural and functional myocardial alterations in patients with repaired tetralogy of fallot: a prospective MRI study.Scientific reports · 2026Article
- Normal myocardial T1, T2 mapping and extracellular volume at 1.5 T in adult Thai population.Journal of applied clinical medical physics · 2026Article
- Human Immunodeficiency Virus-Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure.The Journal of infectious diseases · 2026Article
- Sex-Difference of Associations Between Cigarette Smoking and Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis.Journal of the American Heart Association · 2026Article
- Aging-Induced QT Prolongation as a Potential Contributor to Longevity.Journal of cardiovascular development and disease · 2026Review
- Delaying cardiac aging: potential mechanisms centered on PANoptosis and targeted intervention strategies.Frontiers in cardiovascular medicine · 2026Review
- Cardiac left ventricular MRI texture analysis to derive texture characteristics of a healthy population: clinical implications.European radiology · 2026Article
- Evaluation of myocardial fibrosis and cardiac function in fibrotic lung diseases: a prospective study.Scientific reports · 2025Article
- Exploring sex differences in myocardial fibrosis in patients with structurally normal hearts.Scientific reports · 2025Article
134 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
Abstract
objectivesThis study sought to determine the relationship of cardiovascular magnetic resonance (CMR) measures of tissue composition to age in the Multi-Ethnic Study of Atherosclerosis (MESA).
backgroundAnimal and human studies have demonstrated increased collagen deposition in senescent hearts. New CMR indices of tissue composition by using T1 mapping are sensitive to the presence of myocardial fibrosis.
methodsA total of 1,231 study participants (51% women; age range 54 to 93 years) of the MESA cohort were evaluated with T1 mapping by using 1.5-T CMR scanners. None of the participants had focal scar on delayed enhancement CMR. Single-slice T1 mapping was performed at the midventricular level before and at 12- and 25-min delay after administration of gadolinium contrast by using a modified Look-Locker inversion recovery sequence. The partition coefficient was determined by the slope of the linear relationship of (1/T1myo vs. 1/T1blood). The extracellular volume fraction (ECV) was derived accounting for the hematocrit level. Multivariable regression analyses were performed, adjusting for traditional risk factors and left ventricular structure.
resultsWomen had significantly greater partition coefficient, ECV, and precontrast T1 than men, as well as lower post-contrast T1 values (all p < 0.05). In general, linear regression analyses demonstrated that greater partition coefficient, pre-contrast T1 values, and ECV were associated with older age in men (multivariate regression coefficients = 0.01; 5.9 ms; and 1.04% per 10 years' change; all p < 0.05). ECV was also significantly associated with age in women after multivariable adjustments.
conclusionsCMR parameters that have been associated with myocardial fibrosis were related to older age in the MESA study. Women had higher ECV than men but less ECV change over time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.