ArticleBone2013
In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs.
Article in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Raloxifene Improves Bone Mechanical Properties in Mice Previously Treated with Zoledronate.Calcified tissue international · 2017Article
- Article
- Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model.PloS one · 2017Article
- Assessing the inter- and intra-animal variability ofBone reports · 2016Article
- Strain differences in the attenuation of bone accrual in a young growing mouse model of insulin resistance.Journal of bone and mineral metabolism · 2016Article
- Article
- Article
- Article
- True Gold or Pyrite: A Review of Reference Point Indentation for Assessing Bone Mechanical Properties In Vivo.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Review
- Identifying Novel Clinical Surrogates to Assess Human Bone Fracture Toughness.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Exercise prevents β-aminopropionitrile-induced morphological changes to type I collagen in murine bone.BoneKEy reports · 2015Article
- In vivo reference point indentation measurement variability in skeletally mature inbred mice.BoneKEy reports · 2015Article
- Article
- Novel assessment tools for osteoporosis diagnosis and treatment.Current osteoporosis reports · 2014Review
- Insights into reference point indentation involving human cortical bone: sensitivity to tissue anisotropy and mechanical behavior.Journal of the mechanical behavior of biomedical materials · 2014Article
- Variability of in vivo reference point indentation in skeletally mature inbred rats.Journal of biomechanics · 2014Article
- A novel approach to evaluate the effect of medicaments used in endodontic regeneration on root canal surface indentation.Clinical oral investigations · 2014Article
- Tracing the pathway of compositional changes in bone mineral with age: preliminary study of bioapatite aging in hypermineralized dolphin's bulla.Biochimica et biophysica acta · 2014Article
- In vivo assessment of bone quality in postmenopausal women with type 2 diabetes.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Raloxifene treatment has been shown previously to positively affect bone mechanical properties following 1 year of treatment in skeletally mature dogs. Reference point indentation (RPI) can be used for in vivo assessment of mechanical properties and has been shown to produce values that are highly correlated with properties derived from traditional mechanical testing. The goal of this study was to use RPI to determine if raloxifene-induced alterations in mechanical properties occurred after 6 months of treatment. Twelve skeletally mature female beagle dogs were treated for 6 months with oral doses of saline vehicle (VEH, 1 ml/kg/day) or a clinically relevant dose of raloxifene (RAL, 0.5 mg/kg/day). At 6 months, all animals underwent in vivo RPI (10N force, 10 cycles) of the anterior tibial midshaft. RPI data were analyzed using a custom MATLAB program, designed to provide cycle-by-cycle data from the RPI test and validated against the manufacturer-provided software. Indentation distance increase (IDI), a parameter that is inversely related to bone toughness, was significantly lower in RAL-treated animals compared to VEH (-16.5%), suggesting increased bone toughness. Energy absorption within the first cycle was significantly lower with RAL compared to VEH (-21%). These data build on previous work that has documented positive effects of raloxifene on material properties by showing that these changes exist after 6 months.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.