ArticleNeurotoxicology and teratology
Inadequate intake of nutrients essential for neurodevelopment in children with fetal alcohol spectrum disorders (FASD).
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Choline enhances elicited imitation memory performance in preschool children with prenatal alcohol exposure: a cumulative report of 3 randomized controlled trials.The American journal of clinical nutrition · 2025Trial
- Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.Journal of neurodevelopmental disorders · 2020Trial
- Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders.The American journal of clinical nutrition · 2016Trial
- Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial.The American journal of clinical nutrition · 2015Trial
- Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability.Nutrition research (New York, N.Y.) · 2013Trial
- Stunting, underweight and thinness in internationally adopted children: prevalence and associated factors in a large cohort study.European journal of pediatrics · 2026Article
- Cobalamin Status Among Patients with Fetal Alcohol Spectrum Disorder (FASD)-A Preliminary Study.Nutrients · 2025Article
- Exploring Nutritional Status and Metabolic Imbalances in Children with FASD: A Cross-Sectional Study.Nutrients · 2024Article
- Contribution of ferritin and zinc to adverse infant outcomes among pregnancies with prenatal alcohol exposure in South Africa.Reproductive toxicology (Elmsford, N.Y.) · 2024Article
- Prenatal Alcohol Exposure and Metabolic Disorders in Pediatrics: The Role of the Oxidative Stress-A Review of the Literature.Children (Basel, Switzerland) · 2024Review
- Maternal dietary intake among alcohol-exposed pregnancies is linked to early infant physical outcomes in South Africa.Reproductive toxicology (Elmsford, N.Y.) · 2023Article
- Effects of nutrition and gestational alcohol consumption on fetal growth and development.Nutrition reviews · 2022Review
- Review
- Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function.Neuropsychology review · 2021Review
- Examination of cortically projecting cholinergic neurons following exercise and environmental intervention in a rodent model of fetal alcohol spectrum disorders.Birth defects research · 2021Article
- Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder.PloS one · 2018Article
- Fetal Alcohol Spectrum Disorders: Characteristics, Complications, and Treatment.Community mental health journal · 2017Review
- Dietary Nutrient Intake in School-Aged Children With Heavy Prenatal Alcohol Exposure.Alcoholism, clinical and experimental research · 2016Article
- Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder.The Journal of pediatrics · 2016Article
- Dissecting FASD through the global transcriptome.Alcoholism, clinical and experimental research · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
This study evaluated dietary intake in children with fetal alcohol spectrum disorders (FASD). Pre-clinical research suggests that nutrient supplementation may attenuate cognitive and behavioral deficits in FASD. Currently, the dietary adequacy of essential nutrients in children with FASD is unknown. Dietary data were collected as part of a randomized, double-blind controlled trial of choline supplementation in FASD. Participants included 31 children with FASD, ages 2.5-4.9 years at enrollment. Dietary intake data was collected three times during the nine-month study via interview-administered 24-hour recalls with the Automated Self-Administered 24-hour Recall. Dietary intake of macronutrients and 17 vitamins/minerals from food was averaged across three data collection points. Observed nutrient intakes were compared to national dietary intake data of children ages 2-5 years (What we Eat in America, NHANES 2007-2008) and to the Dietary Reference Intakes. Compared to the dietary intakes of children in the NHANES sample, children with FASD had lower intakes of saturated fat, vitamin D, and calcium. The majority (>50%) of children with FASD did not meet the Recommended Dietary Allowance (RDA) or Adequate Intake (AI) for fiber, n-3 fatty acids, vitamin D, vitamin E, vitamin K, choline, and calcium. This pattern of dietary intake in children with FASD suggests that there may be opportunities to benefit from nutritional intervention. Supplementation with several nutrients, including choline, vitamin D, and n-3 fatty acids, has been shown in animal models to attenuate the cognitive deficits of FASD. These results highlight the potential of nutritional clinical trials in FASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.