ArticleJournal of theoretical biology2013
A dynamical system that describes vein graft adaptation and failure.
Article in Journal of theoretical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models.Frontiers in bioengineering and biotechnology · 2021Review
- A computational bio-chemo-mechanical model of in vivo tissue-engineered vascular graft development.Integrative biology : quantitative biosciences from nano to macro · 2020Article
- A versatile hybrid agent-based, particle and partial differential equations method to analyze vascular adaptation.Biomechanics and modeling in mechanobiology · 2019Article
- A Twofold Usage of an Agent-Based Model of Vascular Adaptation to Design Clinical Experiments.Journal of computational science · 2018Article
- A Computational Model-Based Framework to Plan Clinical Experiments - an Application to Vascular Adaptation Biology.Computational Science--ICCS ... : international conference ... : proceedings. ICCS · 2018Article
- Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications.Molecular aspects of medicine · 2017Review
- Limiting Injury During Saphenous Vein Graft Preparation For Coronary Arterial Bypass Prevents Metabolic Decompensation.Scientific reports · 2017Article
- Vascular Adaptation: Pattern Formation and Cross Validation between an Agent Based Model and a Dynamical System.Journal of theoretical biology · 2017Article
- Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation.Annals of biomedical engineering · 2017Article
- Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts.Frontiers in physiology · 2017Article
- Linking gene dynamics to vascular hyperplasia - Toward a predictive model of vein graft adaptation.PloS one · 2017Article
- Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention.Annals of biomedical engineering · 2016Article
- The correlation between computed tomography and duplex evaluation of autogenous vein bypass grafts and their relationship to failure.Journal of vascular surgery · 2015Article
- A Multiscale Computational Framework to Understand Vascular Adaptation.Journal of computational science · 2015Article
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Authors and funding
2 authors.
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Abstract
Adaptation of vein bypass grafts to the mechanical stresses imposed by the arterial circulation is thought to be the primary determinant for lesion development, yet an understanding of how the various forces dictate local wall remodeling is lacking. We develop a dynamical system that summarizes the complex interplay between the mechanical environment and cell/matrix kinetics, ultimately dictating changes in the vein graft architecture. Based on a systematic mapping of the parameter space, three general remodeling response patterns are observed: (1) shear stabilized intimal thickening, (2) tension induced wall thinning and lumen expansion, and (3) tension stabilized wall thickening. Notable is our observation that the integration of multiple feedback mechanisms leads to a variety of non-linear responses that would be unanticipated by an analysis of each system component independently. This dynamic analysis supports the clinical observation that the majority of vein grafts proceed along an adaptive trajectory, where grafts dilate and mildly thicken in response to the increased tension and shear, but a small portion of the grafts demonstrate a maladaptive phenotype, where progressive inward remodeling and accentuated wall thickening lead to graft failure.
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