ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2014
The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 6 of them syntheses that pooled it.
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Who cites it
81 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Unawareness of deficits in mild cognitive impairment: a systematic review of its role in progression to Alzheimer's disease.BMC neurology · 2026Pooled it
- Cognitive changes preceding Parkinson's disease: a systematic review and meta-analysis of prospective population-based studies.Frontiers in aging neuroscience · 2025Pooled it
- Transitions across cognitive states and death among older adults in relation to education: A multistate survival model using data from six longitudinal studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Pooled it
- From Subjective Cognitive Complaints to Dementia: Who is at Risk?: A Systematic Review.American journal of Alzheimer's disease and other dementias · 2016Pooled it
- Examination of Variables That May Affect the Relationship Between Cognition and Functional Status in Individuals with Mild Cognitive Impairment: A Meta-Analysis.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2016Pooled it
- Association of Subjective Cognitive Decline with Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Longitudinal Studies.The journal of prevention of Alzheimer's diseasePooled it
- Association of the Informant-Reported Memory Decline With Cognitive and Brain Deterioration Through the Alzheimer Clinical Continuum.Neurology · 2023Trial
- Trial
- Association between urate-lowering therapies and cognitive decline in community-dwelling older adults.Scientific reports · 2022Trial
- Separating ECog scale-score information from dyad availability: observation-process contributions to dyadic prediction of cognitive impairment in ADNI.Research square · 2026Article
- The Role of Dyads in Subjective Reporting and Prediction of Cognitive Worsening in Cognitively Unimpaired Individuals and Individuals with Subjective Cognitive Decline: Results of the CompAS Longitudinal Study.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Effect of increasing cognitive activity participation via calligraphy practice on salient network and central executive network in older adults with subjective cognitive decline: a secondary analysis of a randomized controlled trial.Frontiers in aging neuroscience · 2026Article
- Increased Worry Associated with Self-Reported, but Not Informant-Reported, Subjective Cognitive Decline Predicts Increased Risk of Incident Dementia.Diagnostics (Basel, Switzerland) · 2025Article
- Clinical definition, biological characterization, and detection guidelines of subjective cognitive decline due to Alzheimer's disease and related dementia: A position paper from ISTAART SCD PIA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Subjective memory complaints of patients and caregivers and their association with sociodemographic and clinical factors in patients with neurocognitive disorders from Colombia.Research square · 2025Article
- Study partner characteristics moderate the prediction of cognitive decline in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Distinct trajectories of subjective cognitive decline before diagnosis of neurocognitive disorders: Longitudinal modelling over 18 years.The journal of prevention of Alzheimer's disease · 2025Article
- Functional training improves cognitive function, functional fitness, and BDNF levels in older women with mild cognitive impairment: a randomized controlled trial.Frontiers in physiology · 2025Article
- Cognitive status and demographics modify the association between subjective cognition and amyloid.Annals of clinical and translational neurology · 2024Article
- Cognitive performance in patients with neuromyelitis optica: clinical and imaging characteristics.Scientific reports · 2024Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe objective of this study was to compare whether different sources of cognitive complaint (i.e., subjective and informant) predict diagnostic conversion in nondemented older adults.
methodsParticipants from the National Alzheimer's Coordinating Center had a baseline diagnosis of normal cognition (NC; n = 4414; mean age, 73 ± 8 years; 69% female) or mild cognitive impairment (MCI; n = 1843; mean age, 74 ± 8 years; 52% female). Multinomial logistic regression related baseline cognitive complaint (no complaint, self only, informant only, or both self and informant) to diagnostic outcome (reversion, stable, or conversion).
resultsAt follow-up, 14% of NC participants converted to MCI/dementia (3.5 ± 1.8 years), and 41% of MCI participants converted to dementia (3.0 ± 1.6 years). Among NC participants, self complaint only (odds ratio [OR], 2.1; 99% confidence interval (CI),1.5-2.9; P < .001), informant complaint only (OR, 2.2; 99% CI, 1.2-3.9; P < .001), and both self and informant complaint (OR, 4.2; 99% CI, 2.9-6.0; P < .001) were associated with diagnostic conversion compared with no complaint. Among participants with MCI-compared with no complaint, informant complaint only (OR, 2.2; 99% CI, 1.2-4.3, P = .002), and both self and informant complaint (OR, 2.9; 99% CI, 1.8-4.8; P < .001)-were associated with conversion.
conclusionsCognitive complaints are related to conversion among nondemented older adults. Complaint from both (i.e. mutual complaint) sources was most predictive of diagnostic outcome, followed by informant complaint, highlighting the need for obtaining informant corroboration to enhance prognosis and distinguish underlying pathological processes from normal cognitive aging. Self complaint was related inconsistently to diagnostic outcome.
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