Trial reportBMC neuroscience2013
Effects of a cognitive training on spatial learning and associated functional brain activations.
Trial report in BMC neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- The effect of exercise on cognitive function in people with multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.Journal of neurology · 2023Pooled it
- Computerised cognitive training for 12 or more weeks for maintaining cognitive function in cognitively healthy people in late life.The Cochrane database of systematic reviews · 2020Pooled it
- Computerised cognitive training for maintaining cognitive function in cognitively healthy people in midlife.The Cochrane database of systematic reviews · 2019Pooled it
- Computerised cognitive training for maintaining cognitive function in cognitively healthy people in late life.The Cochrane database of systematic reviews · 2019Pooled it
- Computerised cognitive training for preventing dementia in people with mild cognitive impairment.The Cochrane database of systematic reviews · 2019Pooled it
- Effects of functional tasks exercise on cognitive functions of older adults with mild cognitive impairment: a randomized controlled pilot trial.Alzheimer's research & therapy · 2019Trial
- Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study.NeuroImage. Clinical · 2019Trial
- Mechanisms of interventions targeting modifiable factors for dementia risk reduction.Molecular neurodegeneration · 2025Review
- "CityQuest," A Custom-Designed Serious Game, Enhances Spatial Memory Performance in Older Adults.Frontiers in aging neuroscience · 2022Article
- Cognitive and Motor Perseveration Are Associated in Older Adults.Frontiers in aging neuroscience · 2021Article
- Rationale and Design of the PAIRED Trial: Partnered Dance Aerobic Exercise as a Neuroprotective, Motor, and Cognitive Intervention in Parkinson's Disease.Frontiers in neurology · 2020Article
- Virtual environments as memory training devices in navigational tasks for older adults.Scientific reports · 2018Article
- A Cross-Disciplinary Successful Aging Intervention and Evaluation: Comparison of Person-to-Person and Digital-Assisted Approaches.International journal of environmental research and public health · 2018Article
- Lifestyle and neurodegeneration in midlife as expressed on functional magnetic resonance imaging: A systematic review.Alzheimer's & dementia (New York, N. Y.) · 2018Review
- The Aging Navigational System.Neuron · 2017Review
- Cognitive Improvement and Brain Changes after Real-Time Functional MRI Neurofeedback Training in Healthy Elderly and Prodromal Alzheimer's Disease.Frontiers in neurology · 2017Article
- Language lateralization shifts with learning by adults.Laterality · 2015Article
- Plasticity of brain and cognition in older adults.Psychological research · 2014Review
- Resting-state fMRI activity predicts unsupervised learning and memory in an immersive virtual reality environment.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth cognitive and physical exercise have been discussed as promising interventions for healthy cognitive aging. The present study assessed the effects of cognitive training (spatial vs. perceptual training) and physical training (endurance training vs. non-endurance training) on spatial learning and associated brain activation in 33 adults (40-55 years). Spatial learning was assessed with a virtual maze task, and at the same time neural correlates were measured with functional magnetic resonance imaging (fMRI).
resultsOnly the spatial training improved performance in the maze task. These behavioral gains were accompanied by a decrease in frontal and temporal lobe activity. At posttest, participants of the spatial training group showed lower activity than participants of the perceptual training group in a network of brain regions associated with spatial learning, including the hippocampus and parahippocampal gyrus. No significant differences were observed between the two physical intervention groups.
conclusionsFunctional changes in neural systems associated with spatial navigation can be induced by cognitive interventions and seem to be stronger than effects of physical exercise in middle-aged adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.