ArticleNeurobiology of aging2013
Alzheimer's disease risk genes and the age-at-onset phenotype.
Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.JAMA neurology · 2014Pooled it
- Potential biases associated with reported parental history of dementia in the Alzheimer's Disease Research Center cohorts: Implications for secondary data analyses.Journal of Alzheimer's disease : JAD · 2026Article
- Article
- The Role of the Urea Cycle in the Alzheimer's Disease Brain.Journal of neurochemistry · 2025Review
- Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers.Current gene therapy · 2025Review
- Cell type-specific functions of Alzheimer's disease endocytic risk genes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Can Genetic Markers Predict the Sporadic Form of Alzheimer's Disease? An Updated Review on Genetic Peripheral Markers.International journal of molecular sciences · 2023Review
- Exogenous Oxytocin Administration Restores Memory in Female APP/PS1 Mice.Journal of Alzheimer's disease : JAD · 2023Article
- Review
- Review
- Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer's disease patients with pathogenic/likely pathogenic amyloid protein precursor mutations.Frontiers in aging neuroscience · 2022Article
- The role of vascular dementia associated genes in patients with Alzheimer's disease: A large case-control study in the Chinese population.CNS neuroscience & therapeutics · 2021Article
- Alzheimer disease.Nature reviews. Disease primers · 2021Review
- Risk factors for earlier dementia onset in autopsy-confirmed Alzheimer's disease, mixed Alzheimer's with Lewy bodies, and pure Lewy body disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- The Biology of Glial Cells and Their Complex Roles in Alzheimer's Disease: New Opportunities in Therapy.Biomolecules · 2018Review
- Understanding mechanisms and seeking cures for Alzheimer's disease: why we must be "extraordinarily diverse".American journal of physiology. Cell physiology · 2017Review
- A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.Nature neuroscience · 2017Article
- Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Article
- Individual estimates of age at detectable amyloid onset for risk factor assessment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Article
- The Role of PICALM in Alzheimer's Disease.Molecular neurobiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Despite the recent identification of several novel risk genes for Alzheimer's disease (AD), little is known about their influence on the age at onset (AAO) of AD. The AAO is a phenotype with a heritable component distinct from disease risk and may be a useful trait to study in the context of developing interventions for delaying the onset of AD. We studied the influence of 10 recently identified AD risk genes and APOE in relation to AAO in a large cohort of AD patients (N = 2569). We find that the novel AD risk gene, PICALM, exerts a small effect on the AAO of AD with earlier disease onset in risk allele carriers. In addition, we confirmed the previously reported association between the APOE ε4 allele and earlier disease onset. None of the other AD risk genes influenced AAO of AD. Our results suggest that besides APOE, other genes associated with AD risk do not exert large effects on the AAO phenotype of AD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.