ReviewCell host & microbe2013
Revisiting caspase-11 function in host defense.
Review in Cell host & microbe, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- The evolution of regulated cell death pathways in animals and their evasion by pathogens.Physiological reviews · 2022Review
- Pyroptosis in the Initiation and Progression of Atherosclerosis.Frontiers in pharmacology · 2021Review
- Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.Immunity · 2020Article
- Roles of the pyroptosis signaling pathway in a sepsis-associated encephalopathy cell model.The Journal of international medical research · 2020Article
- Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1.Acta pharmacologica Sinica · 2019Article
- SERPINB1-mediated checkpoint of inflammatory caspase activation.Nature immunology · 2019Article
- Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes.EBioMedicine · 2018Article
- Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.PLoS pathogens · 2018Article
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.Cell death and differentiation · 2018Review
- Macrophage-Bacteria Interactions-A Lipid-Centric Relationship.Frontiers in immunology · 2017Review
- Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death.Nature communications · 2016Article
- Apoptosis, Necrosis, and Necroptosis in the Gut and Intestinal Homeostasis.Mediators of inflammation · 2015Review
- Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.Cell host & microbe · 2014Article
- Interaction of Mycobacterium tuberculosis with host cell death pathways.Cold Spring Harbor perspectives in medicine · 2014Review
- Mechanisms that regulate macrophage burden in atherosclerosis.Circulation research · 2014Review
- NOD-Like Receptors in Lung Diseases.Frontiers in immunology · 2013Review
- Immunology. Sensing endotoxins from within.Science (New York, N.Y.) · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Proinflammatory caspases play important roles in innate immunity. Much attention has focused on caspase-1, which acts to eliminate pathogens by obliterating their replicative niches as well as alerting the host to their presence. Now, emerging data have shed light on the lesser-studied proinflammatory caspase-11 in the combat between host and pathogens. Using the new tools available, researchers are further elucidating the mechanisms by which caspase-11 contributes to host defense. Here, we review the emerging understanding of caspase-11 functions and the mechanisms of activation and discuss the implications for human disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.