ArticleBiophysical journal2013
Platelet transport rates and binding kinetics at high shear over a thrombus.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Degree of luminal narrowing and composition of thrombus in plaque erosion.Journal of thrombosis and thrombolysis · 2021Trial
- Impact of Vascular Geometry on Thrombosis in Pediatric Patients With Modified Blalock-Taussig-Thomas Shunt: A Pilot Study.Journal of the American Heart Association · 2025Article
- Article
- Force balance ratio is a robust predictor of arterial thrombus stability.Biophysical journal · 2024Article
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- Multiphysics Modelling and Simulation of Thrombolysis via Activated Platelet-Targeted Nanomedicine.Pharmaceutical research · 2022Article
- Blood Flow Velocimetry in a Microchannel During Coagulation Using Particle Image Velocimetry and Wavelet-Based Optical Flow Velocimetry.Journal of biomechanical engineering · 2021Article
- Biorheology of occlusive thrombi formation under high shear: in vitro growth and shrinkage.Scientific reports · 2020Article
- Impact of superhydrophobicity on the fluid dynamics of a bileaflet mechanical heart valve.Journal of the mechanical behavior of biomedical materials · 2020Article
- Seasonal Variations in the Pathogenesis of Acute Coronary Syndromes.Journal of the American Heart Association · 2020Article
- Engineering a Bi-Conical Microchip as Vascular Stenosis Model.Micromachines · 2019Article
- Clinical and Laboratory Predictors for Plaque Erosion in Patients With Acute Coronary Syndromes.Journal of the American Heart Association · 2019Article
- Hemocompatibility of Super-Repellent surfaces: Current and Future.Materials horizons · 2019Article
- Microfluidic and computational study of structural properties and resistance to flow of blood clots under arterial shear.Biomechanics and modeling in mechanobiology · 2019Article
- Downstream platelet adhesion and activation under highly elevated upstream shear forces.Acta biomaterialia · 2019Article
- Effects of upstream shear forces on priming of platelets for downstream adhesion and activation.Acta biomaterialia · 2018Article
- The Margination of Particles in Areas of Constricted Blood Flow.Biophysical journal · 2018Article
- Impact of Tissue Factor Localization on Blood Clot Structure and Resistance under Venous Shear.Biophysical journal · 2018Article
- Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow.Journal of the Royal Society, Interface · 2017Article
- Multi-Constituent Simulation of Thrombus Deposition.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thrombus formation over a ruptured atherosclerotic plaque cap can occlude an artery with fatal consequences. We describe a computational model of platelet transport and binding to interpret rate-limiting steps seen in experimental thrombus formation over a collagen-coated stenosis. The model is used to compute shear rates in stenoses with growing boundaries. In the model, moving erythrocytes influence platelet transport based on shear-dependent enhanced diffusivity and a nonuniform platelet distribution. Adhesion is modeled as platelet-platelet binding kinetics. The results indicate that observed thrombus growth rates are limited by platelet transport to the wall for shear rates up to 6000 s(-1). Above 7000 s(-1), the thrombus growth rate is likely limited by binding kinetics (10(-4) m/s). Thrombus growth computed from these rate-limiting steps match the thrombus location and occlusion times for experimental conditions if a lag time for platelet activation is included. Using fitted parameters, the model is then used to predict thrombus size and shape at a higher Reynolds number flow consistent with coronary artery disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.