ArticleBiophysical journal2013
Exchangeable colloidal AFM probes for the quantification of irreversible and long-term interactions.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Noninvasive methods to monitor dynamic single-cell events.Trends in cell biology · 2026Review
- Traceable stiffness calibration of colloidal AFM probes for biomechanical measurements.Scientific reports · 2026Article
- Non-invasive biomechanical characterization of embryos using microfluidic cantilevers.European biophysics journal : EBJ · 2026Article
- High-Throughput Mechanical Characterization of Single Microgel Particles by Fluidic Force Microscopy.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Factors influencing initial bacterial adhesion to antifouling surfaces studied by single-cell force spectroscopy.iScience · 2024Article
- Hydrodynamic function and spring constant calibration of FluidFM micropipette cantilevers.Microsystems & nanoengineering · 2024Article
- Evidence of collective influence in innate sensing using fluidic force microscopy.Frontiers in immunology · 2024Article
- Building block properties govern granular hydrogel mechanics through contact deformations.Science advances · 2022Article
- AFM Microfluidic Cantilevers as Weight Sensors for Live Single Cell Mass Measurements.Measurement science & technology · 2022Article
- Extending applications of AFM to fluidic AFM in single living cell studies.Journal of cellular physiology · 2022Review
- Micropipette-based biomechanical nanotools on living cells.European biophysics journal : EBJ · 2022Review
- Non-contact elastography methods in mechanobiology: a point of view.European biophysics journal : EBJ · 2022Review
- Host EPAC1 Modulates Rickettsial Adhesion to Vascular Endothelial Cells via Regulation of ANXA2 Y23 Phosphorylation.Pathogens (Basel, Switzerland) · 2021Article
- Review
- Elasticity spectra as a tool to investigate actin cortex mechanics.Journal of nanobiotechnology · 2020Review
- Article
- Electrokinetics in Micro-channeled Cantilevers: Extending the Toolbox for Reversible Colloidal Probes and AFM-Based Nanofluidics.Scientific reports · 2019Article
- Spring constant and sensitivity calibration of FluidFM micropipette cantilevers for force spectroscopy measurements.Scientific reports · 2019Article
- Correlation of Surface Morphology and Interfacial Adhesive Behavior between Cellulose Surfaces: Quantitative Measurements in Peak-Force Mode with the Colloidal Probe Technique.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Diamond Colloidal Probe Force Spectroscopy.Analytical chemistry · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An original method is presented to study single-colloid interaction with a substrate in liquid environment. Colloids, either in solution or adsorbed on a surface, are fixed by suction against the aperture of a microchanneled atomic force microscopy cantilever. Their adhesion to the substrate is measured, followed by their release via a short overpressure surge. Such colloid exchange procedure allows for 1), the quick variation of differently functionalized colloids within the same experiment; 2), the investigation of long-term interactions by leaving the colloids on a surface for a defined time before detaching them; and 3), the inspection of irreversible interactions. After validation of the method by reproducing literature results obtained with traditional colloidal atomic force microscopy, the serial use of colloids with different surface functionalization was shown on a micropatterned surface. Finally, concanavalin A-coated colloids were allowed to adsorb on human embryonic kidney cells and then detached one by one. The adhesion between cells and colloids was up to 60 nN, whereas individual cells adhered with 20 nN to the glass substrate. A cellular elastic modulus of 0.8 kPa was determined using the attached colloid as indenter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.