ArticleLipids in health and disease2013
Percentages of oleic acid and arachidonic acid are inversely related in phospholipids of human sera.
Article in Lipids in health and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
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- Changes in the Fatty Acid Profile in Erythrocytes in High-Level Endurance Runners during a Sports Season.Nutrients · 2024Article
- A genome-wide association study for the fatty acid composition of breast meat in an F2 crossbred chicken population.Journal of animal science and technology · 2023Article
- Dietary Oxidized Linoleic Acids Modulate Fatty Acids in Mice.Journal of lipid and atherosclerosis · 2022Article
- Intended Ranges and Correlations between Percentages of Variables Like Oleic Acid, Eicosapentaenoic Acid, and Arachidonic Acid.Foods (Basel, Switzerland) · 2021Article
- Hexosylceramides and Glycerophosphatidylcholine GPC(36:1) Increase in Multi-Organ Dysfunction Syndrome Patients with Pediatric Intensive Care Unit Admission over 8-Day Hospitalization.Journal of personalized medicine · 2021Article
- Alteration in the Lipid Profile and the Desaturases Activity in Patients With Severe Pneumonia by SARS-CoV-2.Frontiers in physiology · 2021Article
- Alteration of the Fatty Acid Metabolism in the Rat Kidney Caused by the Injection of Serum from Patients with Collapsing Glomerulopathy.Biomedicines · 2020Article
- Changes in Human Milk Fatty Acid Composition During Lactation: The Ulm SPATZ Health Study.Nutrients · 2019Observational
- The inverse association between relative abundances of oleic acid and arachidonic acid: a case of distribution dependent regulation?Lipids in health and disease · 2019Article
- Short-Term Exposure to High Sucrose Levels near Weaning Has a Similar Long-Lasting Effect on Hypertension as a Long-Term Exposure in Rats.Nutrients · 2018Article
- Lipid Quality in Infant Nutrition: Current Knowledge and Future Opportunities.Journal of pediatric gastroenterology and nutrition · 2015Review
- N-stearoylethanolamine restores pancreas lipid composition in obesity-induced insulin resistant rats.Lipids · 2015Article
- The inverse association between relative abundances of oleic acid and arachidonic acid is related to alpha -linolenic acid.Lipids in health and disease · 2014Article
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2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany health effects of oils rich in oleic acid (18:1 n9) seem to be opposite those of arachidonic acid (20:4 n6), i.e. concerning cardiovascular risk. In recent study in rats we observed that percentages of oleic acid and arachidonic acid were inversely related in total serum lipids. In the present work we investigate whether an inverse relationship between this couple of fatty acids also exists in the phospholipid fraction of human sera.
methodsThe study group consisted of 11 men and 35 women. Mean age was 23.8 ± 2.5 years (mean ± SD), and the body mass index was 23.5 ± 3.2 kg/m2. After fasting overnight, blood was drawn and the concentration of fatty acids in serum phospholipids was determined, using gas chromatography. We studied the association between percentages of oleic acid and arachidonic acid using bivariate correlations (Pearson), and multiple linear regressions.
resultsWe found an inverse relationship (r = -0.563, p < 0.001; n = 46) between % oleic acid and % arachidonic acid in the serum phosholipid fraction of the 46 fasting subjects. By multiple linear regression, and % 20:4 n6 as the dependent variable, the inverse association with % 18:1 n9 persisted when controlling for sex, age, body mass index, and percentages of the other fatty acids measured (t = -17.6, p < 0.001). Per cent 20:4 n6 seemed to correlate negatively (r = -0.289, p = 0.05) with the (18:1 n9)/(18:0) ratio, estimating Delta9 desaturase activity, and % oleic acid correlated negatively (r = -0.321, p = 0.029) with the (20:4)/(18:2) ratio, estimating desaturases/elongase activities.
conclusionsIn a group of healthy human subjects, percentages of oleic acid and arachidonic acid were inversely related, and the inverse association persisted when controlling for possible confounding variables. The findings might contribute to explain positive health effects of foods rich in oleic acid.
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