ArticleCell2013
A network of cadherin-mediated interactions polarizes growth cones to determine targeting specificity.
Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
- Clustered cytoneme interactions contribute to peripheral nervous system patterning in Drosophila.bioRxiv : the preprint server for biology · 2026Article
- Formation of sensory maps: New tools reveal novel insights into neural development.Current opinion in neurobiology · 2025Review
- Glia phagocytose neuronal sphingolipids to infiltrate developing synapses.bioRxiv : the preprint server for biology · 2025Article
- Nervous system-wide analysis of allScience advances · 2025Article
- β-catenin-α-catenin and actomyosin signaling differentially regulate growth cone contours and axon undulation and branching of retinal ganglion cellsFrontiers in cellular neuroscience · 2025Article
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- Novel missense variants in brain morphogenic genes associated with depression and schizophrenia.Frontiers in psychiatry · 2024Article
- Protein O-mannosylation: one sugar, several pathways, many functions.Glycobiology · 2023Review
- Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.PLoS genetics · 2021Article
- Brain inflammation triggers macrophage invasion across the blood-brain barrier inScience advances · 2021Article
- Neural specification, targeting, and circuit formation during visual system assembly.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Establishment and Maintenance of Neural Circuit Architecture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
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- The atypical cadherin flamingo determines the competence of neurons for activity-dependent fine-scale topography.Molecular brain · 2019Article
- Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners.Neuron · 2019Article
- Strategies for assembling columns and layers in the Drosophila visual system.Neural development · 2018Review
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Neuronal growth cones select synaptic partners through interactions with multiple cell surfaces in their environment. Many of these interactions are adhesive, yet it is unclear how growth cones integrate adhesive cues to direct their movements. Here, we examine the mechanisms that enable photoreceptors in the Drosophila visual system to choose synaptic partners. We demonstrate that the classical cadherin, N-cadherin, and an atypical cadherin, Flamingo, act redundantly to instruct the targeting choices made by every photoreceptor axon. These molecules gradually bias the spatial distribution of growth cone filopodia, polarizing each growth cone toward its future synaptic target before direct contact with the target occurs. We demonstrate that these molecules are localized to distinct subcellular domains and create a network of adhesive interactions distributed across many growth cones. Because this network comprises multiple redundant interactions, a complex wiring diagram can be constructed with extraordinary fidelity, suggesting a general principle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.