Evidence map›Paper›PMID 23870118›Full record

ArticleCell2013

Aging: seeking mitonuclear balance.

Jason Karpac, Heinrich Jasper

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Heme oxygenase-1 protects against endotoxin-induced acute lung injury depends on NADInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  2. Mitonuclear genomics and aging.Human genetics · 2020
    Review
  3. MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jason KarpacBuck Institute for Research on Aging, Novato, CA 94945, USA.
Heinrich Jasper
Buck Institute for Research on Aging · US

Funding

Systemic coordination of stress responses by insulin signalingR01AG028127 · NIA · UNIVERSITY OF ROCHESTER · PI JASPER, HEINRICH · 2006 to 2015
$3.0M
Redox Signaling and Stem Cell FunctionR01GM100196 · NIGMS · UNIVERSITY OF ROCHESTER · PI BOHMANN, DIRK, JASPER, HEINRICH · 2012 to 2015
$1.7M
NIA NIH HHS R01 AG028127NIGMS NIH HHS R01 GM100196
6 · The paper itself

Abstract

Metabolic imbalances accompany the aging process in many organisms, and signaling mechanisms that allay or prevent these imbalances can extend lifespan. Two recent studies by Auwerx and colleagues, including one in this issue, identify a conserved signaling network centered on mitochondrial stress responses that promotes longevity in response to changes in mitochondrial translation and NAD(+) metabolism.

Indexed as

LongevitySignal TransductionUnfolded Protein ResponseAnimalsForkhead Transcription FactorsMitochondriaNADForkhead Transcription FactorsNAD

Identifiers

PMID23870118
OpenAlexW2081272321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.