ArticleIndian journal of endocrinology and metabolism2013
Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects.
Article in Indian journal of endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 16 citations in OpenAlex.
- Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathway for Type 2 diabetes pathogenesis.Genes & genomics · 2026Article
- Exploring lipodystrophy gene expression in adipocytes: unveiling insights into the pathogenesis of insulin resistance, type 2 diabetes, and clustering diseases (metabolic syndrome) in Asian Indians.Frontiers in endocrinology · 2024Article
- JAZF1 heterozygous knockout mice show altered adipose development and metabolism.Cell & bioscience · 2021Article
- Differentially Expressed Genes and Enriched Signaling Pathways in the Adipose Tissue of Obese People.Frontiers in genetics · 2021Article
- Article
- Transcriptome profiling reveals association of peripheral adipose tissue pathology with type-2 diabetes in Asian Indians.Adipocyte · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Understanding the role of visceral fat accumulation in the occurrence and progression of metabolic syndrome is of considerable interest. In order to understand the difference between visceral tissue biology of healthy and unhealthy obese individuals, we have used microarray profiling to compare genome-wide expression differences between visceral adipose tissue biopsies obtained from obese diabetics, and those from age and body mass index (BMI) matched normal glucose tolerance subjects. Whereas genes upregulated in diabetics showed enrichment of natural killer cell mediated cytotoxicity, the downregulated genes showed enrichment of biosynthesis of unsaturated fatty acids. Given the known inhibitory effect of unsaturated fatty acids on inflammation and natural killer cell number or activity, our results suggest that visceral inflammation resulting from decreased levels of unsaturated fatty acids may underlie progression of diabetes in obese individuals.
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