ArticlePloS one2013
MicroRNA-326 functions as a tumor suppressor in glioma by targeting the Nin one binding protein (NOB1).
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Robust meta-analysis shows that glioma transcriptional subtyping complements traditional approaches.Cellular oncology (Dordrecht, Netherlands) · 2014Pooled it
- MiR-326: Role and significance in brain cancers.Non-coding RNA research · 2025Review
- ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas.Frontiers in molecular biosciences · 2025Article
- miR-326 overexpression inhibits colorectal cancer cell growth and proteasome activity by targeting PNO1: unveiling a novel therapeutic intervention strategy.Scientific reports · 2024Article
- circRNA-SMO upregulates CEP85 to promote proliferation and migration of glioblastoma via sponging miR-326.Histology and histopathology · 2023Article
- MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma.Cancer science · 2023Article
- miRNA-612 suppresses ovarian cancer cell tumorigenicity by downregulating NOB1.American journal of translational research · 2022Article
- Circular RNA circHIPK3 promotes breast cancer progression via sponging MiR-326.Cell cycle (Georgetown, Tex.) · 2021Article
- Circulating microRNAs in Early Breast Cancer Patients and Its Association With Lymph Node Metastases.Frontiers in oncology · 2021Article
- Establishment of an Immune-Related Gene Signature for Risk Stratification for Patients with Glioma.Computational and mathematical methods in medicine · 2021Article
- Article
- Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer.Cancer medicine · 2020Article
- Expression of miR-495 and miR-326 in peripheral blood of rheumatoid arthritis patients and its significance.Experimental and therapeutic medicine · 2020Article
- Long non-coding RNA NBAT1 inhibits the progression of glioma through the miR-21/SOX7 axis.Oncology letters · 2020Article
- Multivariate analysis reveals differentially expressed genes among distinct subtypes of diffuse astrocytic gliomas: diagnostic implications.Scientific reports · 2020Article
- The value of circulating microRNAs for early diagnosis of B-cell lymphoma: A case-control study on historical samples.Scientific reports · 2020Article
- Recent Trends of microRNA Significance in Pediatric Population Glioblastoma and Current Knowledge of Micro RNA Function in Glioblastoma Multiforme.International journal of molecular sciences · 2020Review
- Assessment of miR-98-5p, miR-152-3p, miR-326 and miR-4289 Expression as Biomarker for Prostate Cancer Diagnosis.International journal of molecular sciences · 2019Review
- MiR-326: Promising Biomarker for Cancer.Cancer management and research · 2019Review
- Non-Coding RNAs in Glioma.Cancers · 2018Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant glioma is the most common type of primary brain tumor in adults, characterized by rapid tumor growth and infiltration of tumor cells throughout the brain. Alterations in the activity of the 26S proteasome have been associated with malignant glioma cells, although the specific defects have not been identified. Recently, microRNA-326 (miR-326) was shown to play an important role in glioblastoma and breast cancer, but the underlying molecular mechanisms remain unclear. In the present study, the human Nin one binding protein (NOB1) was identified as a direct target of miR-326 and a potential oncogene in human glioma. Similar to NOB1 silencing by shRNA, overexpression of miR-326 in human glioma cell lines (A172 and U373) caused cell cycle arrest at the G1 phase, delayed cell proliferation and enhanced apoptosis. MiR-326 inhibited colony formation in soft agar and decreased growth of a xenograft tumor model, suggesting that miR-326 and NOB1 are required for tumorigenesis in vitro and in vivo. Furthermore, these processes were shown to involve the MAPK pathway. NOB1 overexpression in human glioma samples was detected by Affymetrix array analysis, and NOB1 mRNA and protein levels were shown to be increased in high-grade glioma compared to low-grade glioma and normal brain tissue. Furthermore, high levels of NOB1 were associated with unfavorable prognosis of glioma patients. Taken together, these results indicate that miR-326 and NOB1 may play an important role in the development of glioma.
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