ArticleJournal of human reproductive sciences2013
Nicotine alters male reproductive hormones in male albino rats: The role of cessation.
Article in Journal of human reproductive sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- The Smoky Impact of Nicotinic Acetylcholine Receptors on Testicular Function.Journal of clinical medicine · 2024Review
- Article
- An overview of the methamphetamine effect on male sexual behavior and reproductive system.Physiological research · 2023Review
- Circulating ghrelin changes as a biomarker of the stress response and craving in abstinent smokers.Pharmacology, biochemistry, and behavior · 2022Article
- Evaluation of secondary electronic cigarette inhalation on lipid metabolism in C57BL/6J mice using indirect calorimetry.Metabolism open · 2021Article
- The amelioration of nicotine-induced reproductive impairment in male mouse byAnatomy & cell biology · 2021Article
- Environmental and occupational exposures associated with male infertility.Arhiv za higijenu rada i toksikologiju · 2021Review
- Ameliorative effect of fractionated low-dose gamma radiation in combination with ellagic acid on nicotine-induced hormonal changes and testicular toxicity in rats.Environmental science and pollution research international · 2021Article
- Male infertility due to testicular disorders.The Journal of clinical endocrinology and metabolism · 2021Review
- The Prevalence and Components of Metabolic Syndrome in Men from Infertile Couples and Its Relation on Semen Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Waterpipe Tobacco Smoke Exposure during Lactation-Susceptibility of Reproductive Hormones and Oxidative Stress Parameters in Male Progeny Rats.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Chemotherapeutic Potential ofAntibiotics (Basel, Switzerland) · 2020Article
- The influence of smoking exposure and cessation on penile hemodynamics and corporal tissue in a rat model.Translational andrology and urology · 2020Article
- Substance Abuse and Male Hypogonadism.Journal of clinical medicine · 2019Review
- Testosterone and testicular changes in F1 offspring of Wistar rats maternally exposed to nicotine during gestation.JBRA assisted reproduction · 2018Article
- Melatonin ameliorates testicular damages induced by nicotine in mice.Iranian journal of basic medical sciences · 2018Article
- Smoke, alcohol and drug addiction and male fertility.Reproductive biology and endocrinology : RB&E · 2018Review
- Fertility hormones and vitamin E in active and passive adult male smokers in Calabar, Nigeria.PloS one · 2018Article
- Chronic Water-Pipe Smoke Exposure Induces Injurious Effects to Reproductive System in Male Mice.Frontiers in physiology · 2017Article
- N (G)-nitro-L-arginine Methyl Ester Protects Against Hormonal Imbalances Associated with Nicotine Administration in Male Rats.North American journal of medical sciences · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe use of nicotine through smoking remains a serious health problem. It has been associated with reduced fertility, although the mechanism responsible is still unclear. The present study was designed to investigate whether nicotine-induced infertility is associated with altered male reproductive hormones in male albino rats. MATERIALS AND
methodsForty male rats were divided equally into five groups and treated orally for thirty days. Group I, which served as the control received 0.2 ml/kg normal saline, Group II and III received 0.5 mg/kg (low dose) and 1.0 mg/kg (high dose) body weight of nicotine, respectively. The fourth and fifth groups were gavaged with 0.5 mg/kg and 1.0 mg/kg body weight of nicotine but were left untreated for another 30 days. These groups served as the recovery groups. Serum was analyzed for testosterone, luteinizing hormone (LH), follicle stimulating hormones (FSH), and prolactin using radioimmunoassay.
resultsResults showed that nicotine administration significantly decreased (P < 0.05) testosterone in the low and high treated groups and FSH in the high dose treated group when compared with the control group. There was a significant increase (P < 0.05) in mean LH and prolactin level in the high dose treated group when compared with the control. However, the values of the recovery groups were comparable with the control.
conclusionThe findings in this study suggest that nicotine administration is associated with distorted reproductive hormones in male rats although ameliorated by nicotine cessation. It is plausible that the decreased testosterone level is associated with testicular dysfunction rather than a pituitary disorder.
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