ArticleJournal of Indian Society of Periodontology2013
Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress.
Article in Journal of Indian Society of Periodontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The assessment of stress, depression, and inflammation as a collective risk factor for periodontal diseases: a systematic review.Clinical oral investigations · 2020Pooled it
- A Systematic Review and Meta-Analysis of Heart Rate Variability in Assessing Surgeons' Stress Levels.Healthcare (Basel, Switzerland) · 2026Review
- Salivary chromogranin A levels in periodontal health status: a cross-sectional study evaluating clinical and psychological associations.BMC oral health · 2025Article
- The Relationship Between Mental Health and Periodontal Disease: Insights from NHANES Data.F1000Research · 2024Article
- Saliva stress biomarkers in ERCP trainees before and after familiarisation with ERCP on a virtual simulator.Frontiers in surgery · 2024Article
- Psychological stress: neuroimmune roles in periodontal disease.Odontology · 2023Review
- Salivary cortisol, dehydroepiandrosterone, and chromogranin A levels in patients with gingivitis and periodontitis and a novel biomarker for psychological stress.Frontiers in endocrinology · 2023Article
- Associations between chronic work stress and plasma chromogranin A/catestatin among healthy workers.Journal of occupational health · 2022Article
- Is there association between stress and periodontitis?Clinical oral investigations · 2020Article
- Serotonin Transporter (Frontiers in genetics · 2019Article
- From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases.Frontiers in endocrinology · 2019Review
- Catestatin, vasostatin, cortisol, and pain assessments in dogs suffering from traumatic bone fractures.BMC research notes · 2017Article
- Catestatin and vasostatin concentrations in healthy dogs.Acta veterinaria Scandinavica · 2017Article
- Neuroprotective effects of melatonin administration against chronic immobilization stress in rats.International journal of physiology, pathophysiology and pharmacology · 2017Article
- Correlation between Surgeon's experience, surgery complexity and the alteration of stress related physiological parameters.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe psychosocial stress has long been regarded as a significant pre-disposing factor for periodontal disease. The association between the periodontal disease and the neuroendocrine hormones has been observed. Chromogranin A (CgA) is supposed to link the activity of the neuroendocrine system to local and systemic immune functions and to be related to periodontitis.
aimsThe aim of this study was to determine the CgA levels in saliva and plasma in periodontal health and disease and to assess their potential relationship to periodontitis. SETTINGS AND DESIGNS: In this case-control study, the association between periodontal disease and stress marker has been assessed. MATERIALS AND
methodsSIXTY SUBJECTS WERE CHOSEN FOR THIS STUDY: With case group comprising of 30 subjects with chronic periodontitis and control group comprising of 30 healthy subjects. Salivary and plasma CgA levels were determined by ELISA technique. Clinical parameters included were plaque index, papillary bleeding index and clinical attachment loss and probing depth. Correlation analysis was calculated by independent sample t-test.
resultsSignificantly higher CgA levels were found in saliva and plasma of patients with chronic periodontitis compared with healthy individuals (P < 0.05). No significant difference were observed between salivary and plasma CgA levels.
conclusionsThe elevated level CgA in the plasma and saliva of subjects with stress induced chronic periodontitis has yielded insights into biological plausible association between the psychosocial stress and chronic periodontitis. Thus, our results suggest that CgA is a useful biomarker for evaluating at least in part the etiopathogenesis of periodontitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.