Evidence map›Paper›PMID 23869062›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013

Estrogen replacement and skeletal muscle: mechanisms and population health.

Peter M Tiidus, Dawn A Lowe, Marybeth Brown

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04458662 (Iron and Muscular Damage), which is not on this map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04458662 completednot on this mapstarted 2017, after this paper: background citation

Iron and Muscular Damage: FEmale Metabolism and Menstrual Cycle During Exercise

Typeobservational_patient_registrySponsorUniversidad Politecnica de MadridRan2017 to 2020Enrolled103ConditionsIron-deficiency, Inflammation, Exercise Induced Iron-deficiency, Exercise Induced Muscle DamageArmsInterval running protocol / eccentric-based resistance exercise protocol
3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Trial
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  3. Sex hormones and menopause hormone therapy predict muscle strength across the lifespan.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Peter M TiidusDepartment of Kinesology and Physical Education, Wilfrid Laurier University, Waterloo Ontario, Canada;
Dawn A Lowe
Marybeth Brown

Funding

Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4M
NIA NIH HHS R01 AG031743
6 · The paper itself

Abstract

There is a growing body of information supporting the beneficial effects of estrogen and estrogen-based hormone therapy (HT) on maintenance and enhancement of muscle mass, strength, and connective tissue. These effects are also evident in enhanced recovery from muscle atrophy or damage and have significant implications particularly for the muscular health of postmenopausal women. Evidence suggests that HT will also help maintain or increase muscle mass, improve postatrophy muscle recovery, and enhance muscle strength in aged females. This is important because this population, in particular, is at risk for a rapid onset of frailty. The potential benefits of estrogen and HT relative to skeletal muscle function and composition combined with other health-related enhancements associated with reduced risk of cardiovascular events, overall mortality, and metabolic dysfunction, as well as enhanced cognition and bone health cumulate in a strong argument for more widespread and prolonged consideration of HT if started proximal to menopausal onset in most women. Earlier reports of increased health risks with HT use in postmenopausal women has led to a decline in HT use. However, recent reevaluation regarding the health effects of HT indicates a general lack of risks and a number of significant health benefits of HT use when initiated at the onset of menopause. Although further research is still needed to fully delineate its mechanisms of action, the general use of HT by postmenopausal women, to enhance muscle mass and strength, as well as overall health, with initiation soon after the onset of menopause should be considered.

Indexed as

Estrogen Replacement TherapyEstrogensFemaleHumansMuscle, SkeletalMuscle StrengthPostmenopauseWomen's HealthEstrogenscollagenestrogenhealthhormone replacementmuscle

Identifiers

PMID23869062
PMCPMC5504400

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.