Evidence map›Paper›PMID 23868877›Full record

ArticleThe Journal of infectious diseases2013

Highly pathogenic avian influenza A(H5N1) mutants transmissible by air are susceptible to human and animal neutralizing antibodies.

Lanying Du, Ye Li, Guangyu Zhao, Lili Wang, Peng Zou, Lu Lu, Yusen Zhou, Shibo Jiang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Lanying DuLindsley F. Kimball Research Institute, New York Blood Center, New York City.
Ye Li
Guangyu Zhao
Lili Wang
Peng Zou
Lu Lu
Yusen Zhou
Shibo Jiang
New York Blood Center · USInstitute of Microbiology · BYShanghai Medical College of Fudan University · CN

Funding

Rational design of M2e-FP conserved epitope-based universal influenza A vaccinesR03AI088449 · NIAID · NEW YORK BLOOD CENTER · PI DU, LANYING · 2011 to 2012
$162k
NIAID NIH HHS R03 AI088449NIAID NIH HHS R03AI088449
6 · The paper itself

Abstract

A laboratory-generated reassortant H5 hemagglutinin (HA)/influenza A(H1N1) strain containing 4 mutations in influenza A(H5N1) HA has become transmissible by air among mammals. Here, we constructed 15 influenza A(H5N1) pseudoviruses containing a single mutation or a combination of mutations and showed that the pseudoviruses were susceptible to neutralizing antibodies from patients with influenza A(H5N1) infection and from mice immunized with a vaccine containing the conserved HA1 sequence of influenza A(H5N1). These results indicate that antibodies in patients currently infected by influenza A(H5N1) and antibodies induced by vaccines containing conserved sequences in HA1 of wild-type influenza A(H5N1) are highly effective in cross-neutralizing future influenza A(H5N1) mutants with airborne transmissibility, suggesting that human influenza pandemics caused by these influenza A(H5N1) variants can be prevented.

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralHumansInfluenza A Virus, H5N1 SubtypeInfluenza, HumanInfluenza VaccinesMiceNeutralization TestsAntibodies, NeutralizingAntibodies, ViralInfluenza VaccinesAir-transmissibilityH5N1 influenza virusNeutralizing antibodiesPatient serum specimens

Identifiers

PMID23868877
PMCPMC3778968
OpenAlexW2137143631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.