ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2013
Homosexuality via canalized sexual development: a testing protocol for a new epigenetic model.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Revisiting Infanticide in Non-Human Primates Reveals a Similar Likelihood of Male and Female Perpetrators.American journal of primatology · 2026Pooled it
- Genetic and Environmental Influences on Sexual Orientation: Moderation by Childhood Gender Nonconformity and Early-Life Adversity.Archives of sexual behavior · 2024Article
- A broader cultural view is necessary to study the evolution of sexual orientation.Nature ecology & evolution · 2024Article
- Mental Health Disparities Mediating Increased Risky Sexual Behavior in Sexual Minorities: A Twin Approach.Archives of sexual behavior · 2020Article
- Male Ejaculatory Endophenotypes: Revealing Internal Inconsistencies of the Concept in Heterosexual Copulating Rats.Frontiers in behavioral neuroscience · 2020Article
- An alternative hypothesis for the evolution of same-sex sexual behaviour in animals.Nature ecology & evolution · 2019Review
- Associations of Bisexuality and Homosexuality with Handedness and Footedness: A Latent Variable Analysis Approach.Archives of sexual behavior · 2019Article
- Review
- Review
- A test of genetic models for the evolutionary maintenance of same-sex sexual behaviour.Proceedings. Biological sciences · 2015Article
- The search for human pheromones: the lost decades and the necessity of returning to first principles.Proceedings. Biological sciences · 2015Review
- Human homosexuality: a paradigmatic arena for sexually antagonistic selection?Cold Spring Harbor perspectives in biology · 2015Review
- On the evolutionary origins of differences in sexual preferences.Frontiers in psychology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently synthesized and reinterpreted published studies to advance an epigenetic model for the development of homosexuality (HS). The model is based on epigenetic marks laid down in response to the XX vs. XY karyotype in embryonic stem cells. These marks boost sensitivity to testosterone in XY fetuses and lower it in XX fetuses, thereby canalizing sexual development. Our model predicts that a subset of these canalizing epigenetic marks stochastically carry over across generations and lead to mosaicism for sexual development in opposite-sex offspring--the homosexual phenotype being one such outcome. Here, we begin by outlining why HS has been under-appreciated as a commonplace phenomenon in nature, and how this trend is currently being reversed in the field of neurobiology. We next briefly describe our epigenetic model of HS, develop a set of predictions, and describe how epigenetic profiles of human stem cells can provide for a strong test of the model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.