ArticleAnnals of neurology2013
JC virus granule cell neuronopathy and GCN-IRIS under natalizumab treatment.
Article in Annals of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Cerebellar syndrome in a man treated with natalizumab: From the National Multiple Sclerosis Society Case Conference Proceedings.Neurology(R) neuroimmunology & neuroinflammation · 2019Article
- VZV-associated acute retinal necrosis in a patient with MS treated with natalizumab.Neurology(R) neuroimmunology & neuroinflammation · 2018Article
- Natalizumab granule cell neuronopathy: FDG-PET in diagnosis and immune reconstitution with G-CSF.Neurology(R) neuroimmunology & neuroinflammation · 2017Article
- JC virus granule cell neuronopathy onset two months after chemotherapy for low-grade lymphoma.Cerebellum & ataxias · 2017Article
- [Progressive multifocal leukoencephalopathy].Der Nervenarzt · 2016Review
- JC Virus Infects Neurons and Glial Cells in the Hippocampus.Journal of neuropathology and experimental neurology · 2016Article
- Concomitant granule cell neuronopathy in patients with natalizumab-associated PML.Journal of neurology · 2016Article
- Stratification and monitoring of natalizumab-associated progressive multifocal leukoencephalopathy risk: recommendations from an expert group.Journal of neurology, neurosurgery, and psychiatry · 2016Review
- Immunology of progressive multifocal leukoencephalopathy.Journal of neurovirology · 2015Review
- Simian Virus 40 Infection in the Spinal Cord of Simian Immunodeficiency Virus-Immunosuppressed Rhesus Macaques.Journal of neuropathology and experimental neurology · 2015Article
- Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy.Science translational medicine · 2015Article
- Risk Mitigation Strategies for Adverse Reactions Associated with the Disease-Modifying Drugs in Multiple Sclerosis.CNS drugs · 2015Review
- Lack of Major Histocompatibility Complex Class I Upregulation and Restrictive Infection by JC Virus Hamper Detection of Neurons by T Lymphocytes in the Central Nervous System.Journal of neuropathology and experimental neurology · 2015Article
- Case report of a patient with progressive multifocal leukoencephalopathy under treatment with dimethyl fumarate.BMC neurology · 2015Article
- Neurological immune reconstitution inflammatory response: riding the tide of immune recovery.Current opinion in neurology · 2015Review
- Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area.Current opinion in neurology · 2015Review
- Heterogeneous imaging characteristics of JC virus granule cell neuronopathy (GCN): a case series and review of the literature.Journal of neurology · 2015Review
- JCV GCN in a natalizumab-treated MS patient is associated with mutations of the VP1 capsid gene.Neurology · 2014Article
- A fatal case of JC virus meningitis presenting with hydrocephalus in a human immunodeficiency virus-seronegative patient.Annals of neurology · 2014Article
- Gone over to the dark side: Natalizumab-associated JC virus infection of neurons in cerebellar gray matter.Annals of neurology · 2013Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progressive multifocal leukoencephalopathy is the most common clinical presentation of JC virus (JCV)-associated central nervous system (CNS) disease and has emerged as a major safety concern in multiple sclerosis patients treated with the monoclonal antibody natalizumab. Here we report clinical, radiological, and histological findings of a case of cerebellar granule cell neuronopathy (GCN), a JCV-associated CNS disease, so far unreported amongst patients treated with natalizumab. GCN should be considered as a JCV CNS manifestation in patients with newly developed, progressive cerebellar signs under natalizumab treatment, especially in cases where cerebellar atrophy can be visualized by magnetic resonance imaging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.