ArticleNature2013
Myomaker is a membrane activator of myoblast fusion and muscle formation.
Article in Nature, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 359 papers.
What it found
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Who cites it
359 citing papers in PubMed, 564 citations in OpenAlex.
- Dosage-sensitive regulation of Cofilin-1 and LIMK signaling controls myoblast differentiation and fusion.Cellular and molecular life sciences : CMLS · 2026Article
- GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD.Molecular therapy. Nucleic acids · 2026Article
- Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration.Journal of cachexia, sarcopenia and muscle · 2026Review
- Elizabeth Chen is elected to the U.S. National Academy of Sciences.Skeletal muscle · 2026Article
- Changes in gene expression at the early stages of barramundi (Lates calcarifer) muscle cell line development.Molecular biology reports · 2026Article
- Establishment and Characterization of an Immortalized Porcine Satellite Cell Line from China Junmu No.1 Pigs.Veterinary sciences · 2026Article
- Cell fusion after wounding requires plasma membrane damage and endocytosis.bioRxiv : the preprint server for biology · 2026Article
- Comparative transcriptome analysis reveals the coordinated regulation of the miR-34c-5p/AASS axis in chicken skeletal muscle development and intramuscular fat deposition.Food chemistry. Molecular sciences · 2026Article
- Progress on cell therapy for skeletal muscle disorders.Advanced drug delivery reviews · 2026Review
- Aldh3a1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to amyotrophic lateral sclerosis progression.Free radical biology & medicine · 2026Article
- Multimodality Craniofacial Phenotyping of Congenital Facial Weakness Disorders.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Cardiomyocyte fusion contributes to cardiac hypertrophy in adult hearts.Molecular medicine (Cambridge, Mass.) · 2026Article
- TEAD4 Promotes Myogenic Differentiation of Porcine Skeletal Muscle Satellite Cells.Animals : an open access journal from MDPI · 2026Article
- Chondrolectin regulates the sublaminar localization and regenerative function of muscle satellite cells in mice.iScience · 2026Article
- Computational design of membrane fusion proteins.bioRxiv : the preprint server for biology · 2026Article
- Picalm coordinates clathrin-mediated endocytosis and actin remodeling during myogenesis.Molecular metabolism · 2026Article
- Critical regulatory pathways for the development of sheep myoblasts and the enhancement of cultured meat quality.Food chemistry: X · 2026Article
- Physical exercise protects against Toxoplasma gondii infection-induced muscle atrophy and microvascular rarefaction.Communications biology · 2026Article
- Myomaker and Myomixer are required for craniofacial myoblast fusion in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Article
299 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Fusion of myoblasts is essential for the formation of multi-nucleated muscle fibres. However, the identity of muscle-specific proteins that directly govern this fusion process in mammals has remained elusive. Here we identify a muscle-specific membrane protein, named myomaker, that controls myoblast fusion. Myomaker is expressed on the cell surface of myoblasts during fusion and is downregulated thereafter. Overexpression of myomaker in myoblasts markedly enhances fusion, and genetic disruption of myomaker in mice causes perinatal death due to an absence of multi-nucleated muscle fibres. Remarkably, forced expression of myomaker in fibroblasts promotes fusion with myoblasts, demonstrating the direct participation of this protein in the fusion process. Pharmacological perturbation of the actin cytoskeleton abolishes the activity of myomaker, consistent with previous studies implicating actin dynamics in myoblast fusion. These findings reveal a long-sought myogenic fusion protein that controls mammalian myoblast fusion and provide new insights into the molecular underpinnings of muscle formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.