Evidence map›Paper›PMID 23868191›Full record

ArticleJournal of the American Heart Association2013

Biomarkers of dairy fatty acids and risk of cardiovascular disease in the Multi-ethnic Study of Atherosclerosis.

Marcia C de Oliveira Otto, Jennifer A Nettleton, Rozenn N Lemaitre, Lyn M Steffen, Daan Kromhout, Stephen S Rich, Michael Y Tsai, David R Jacobs, Dariush Mozaffarian

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 132 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Marcia C de Oliveira OttoDepartment of Epidemiology, Harvard School of Public Health, Boston, MA.
Jennifer A Nettleton
Rozenn N Lemaitre
Lyn M Steffen
Daan Kromhout
Stephen S Rich
Michael Y Tsai
David R Jacobs
Dariush Mozaffarian
University of Minnesota · USBrigham and Women's Hospital · USHarvard University · USThe University of Texas at Austin · USUniversity of Virginia · USUniversity of Washington · USWageningen University & Research · NL

Funding

Endogenous Anti-Inflammatory Lipid Mediators, Fish Oil and Post-Operative AtrialR21HL109924 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI MOZAFFARIAN, DARIUSH · 2012 to 2013
$432k
NHLBI NIH HHS R21 HL109924
6 · The paper itself

Abstract

backgroundEvidence regarding the role of dairy fat intake in cardiovascular disease (CVD) has been mixed and inconclusive. Most earlier studies have used self-reported measures of dietary intake and focused on relatively racially homogeneous populations. Circulating biomarkers of dairy fat in a multiethnic cohort provide objective measures of dairy fat intake and facilitate conclusions relevant to populations with different diets and susceptibility to CVD. METHODS AND

resultsIn a multiethnic cohort of 2837 US adults aged 45 to 84 years at baseline (2000-2002), phospholipid fatty acids including 15:0, 14:0, and trans-16:1n7 were measured using standardized methods, and the incidence of CVD prospectively adjudicated. Self-reported whole-fat dairy and butter intakes had strongest associations with 15:0, rather than 14:0 or trans-16:1n7. In multivariate models including demographics and lifestyle and dietary habits, each SD-unit of 15:0 was associated with 19% lower CVD risk (hazard ratio [95% CI] 0.81 [0.68 to 0.98]) and 26% lower coronary heart disease (CHD) risk (0.74 [0.60 to 0.92]). Associations were strengthened after mutual adjustment for 14:0 and trans-16:1n-7 and were similar after adjustment for potential mediators. Plasma phospholipid 14:0 and trans-16:1n-7 were not significantly associated with incident CVD or CHD. All findings were similar in white, black, Hispanic, and Chinese American participants.

conclusionPlasma phospholipid 15:0, a biomarker of dairy fat, was inversely associated with incident CVD and CHD, while no association was found with phospholipid 14:0 and trans-16:1n-7. These findings support the need for further investigation of CVD effects of dairy fat, dairy-specific fatty acids, and dairy products in general.

Indexed as

Dairy ProductsAgedAged, 80 and overBiomarkersCardiovascular DiseasesCross-Sectional StudiesDietary FatsFatty AcidsFeeding BehaviorFemaleHumansIncidenceLife StyleLinear ModelsMaleMiddle AgedBiomarkersDietary FatsFatty AcidsPhospholipidscardiovascular diseasesdairy fatdietfatty acids

Identifiers

PMID23868191
PMCPMC3828802
OpenAlexW2140239376

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.