Trial reportJournal of perinatology : official journal of the California Perinatal Association2013
Impact of early surfactant and inhaled nitric oxide therapies on outcomes in term/late preterm neonates with moderate hypoxic respiratory failure.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Early use of combined exogenous surfactant and inhaled nitric oxide reduces treatment failure in persistent pulmonary hypertension of the newborn: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials.Trials · 2014Trial
- Management of Hypoxemic Respiratory Failure in the Newborn During Therapeutic Hypothermia.Clinics in perinatology · 2026Review
- Comparison of neonatal outcomes of term neonates with meconium-stained amniotic fluid before and after routine endotracheal suctioning strategy at birth.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Effectiveness of A Respiratory Care Protocol Including Less Invasive Surfactant Administration in ≥ 35 Weeks Gestational Age Infants.Pediatric pulmonology · 2025Article
- Meconium Aspiration Syndrome, Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia-A Recipe for Severe Pulmonary Hypertension?Children (Basel, Switzerland) · 2024Review
- Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn.American journal of perinatology · 2023Article
- Decreased Cyclic Guanosine Monophosphate-Protein Kinase G Signaling Impairs Angiogenesis in a Lamb Model of Persistent Pulmonary Hypertension of the Newborn.American journal of respiratory cell and molecular biology · 2021Article
- Pathophysiology and Management of Persistent Pulmonary Hypertension of the Newborn.Clinics in perinatology · 2021Review
- Neonatal respiratory and cardiac ECMO in Europe.European journal of pediatrics · 2021Review
- Surf early to higher tides: surfactant therapy to optimize tidal volume, lung recruitment, and iNO response.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Neonatal respiratory extracorporeal membrane oxygenation and primary diagnosis: trends between two decades.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- NICU Admissions for Meconium Aspiration Syndrome before and after a National Resuscitation Program Suctioning Guideline Change.Children (Basel, Switzerland) · 2019Article
- Observational
- Response to pulmonary vasodilators in infants with congenital diaphragmatic hernia.Pediatric surgery international · 2018Article
- Current Practices and Attitudes Regarding Use of Inhaled Nitric Oxide in the NICU: Results From a Survey of Members of the National Association of Neonatal Nurse Practitioners.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2018Article
- Persistent Pulmonary Hypertension in the Newborn.Children (Basel, Switzerland) · 2017Review
- Inhaled nitric oxide therapy for pulmonary disorders of the term and preterm infant.Seminars in perinatology · 2016Review
- Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2016Review
- Challenges, priorities and novel therapies for hypoxemic respiratory failure and pulmonary hypertension in the neonate.Journal of perinatology : official journal of the California Perinatal Association · 2016Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveWe conducted a post-hoc analysis of early inhaled nitric oxide (iNO)-randomized controlled trial data to identify associations pertinent to the management of moderate hypoxic respiratory failure in term/late preterm infants. STUDY
designUnivariate and multivariate logistic regression analyses were used to determine risk factors for the progression of respiratory failure and extracorporeal membrane oxygenation (ECMO)/death.
resultAmong the 299 enrolled infants, oxygenation index (OI) <20 at enrollment (odds ratio 0.52, confidence interval (CI) 0.27 to 0.97) and surfactant use before randomization (odds ratio 0.47, CI 0.24 to 0.91) were associated with decreased ECMO/death rates. Early surfactant use for respiratory distress syndrome, perinatal aspiration syndrome and pneumonia/sepsis was associated with lower risk of ECMO/death (P<0.001). Early iNO (OI 15 to 25) decreased the progression of respiratory failure to OI >30 (P=0.002) and to composite outcome of OI >30 or ECMO/death (P=0.02).
conclusionThis post-hoc analysis suggests that early use of surfactant and iNO in moderate respiratory failure is associated with improved outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.