ArticleInternational journal of oral science2013
Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions.
Article in International journal of oral science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- Sphingosine synergizes with polymyxin antibiotics againstMicrobiology (Reading, England) · 2026Article
- Phytosphingosine disrupts dual-species oral biofilms and attenuates LPS-induced pro-inflammatory responses in human gingival fibroblasts.Scientific reports · 2026Article
- TheMicrobiology (Reading, England) · 2025Article
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- VaginalbioRxiv : the preprint server for biology · 2023Article
- Green Alternatives as Antimicrobial Agents in Mitigating Periodontal Diseases: A Narrative Review.Microorganisms · 2023Review
- Antimicrobial Effect ofArchives of Razi Institute · 2022Article
- Synthesis, Characterization and Biological Evaluation of Novel Benzamidine Derivatives: Newer Antibiotics for Periodontitis Treatment.Antibiotics (Basel, Switzerland) · 2022Article
- Dual Inhibitory Activity of Petroselinic Acid Enriched in Fennel AgainstFrontiers in microbiology · 2022Article
- Antimicrobial Tear Lipids in the Ocular Surface Defense.Frontiers in cellular and infection microbiology · 2022Review
- Push Out Bond Strength of a Glass Fibre Post to Root Dentine Pretreated with Proanthocyanidin and Phytosphingosine - An In Vitro Study.European endodontic journal · 2021Article
- Staphylococcus aureus Releases Proinflammatory Membrane Vesicles To Resist Antimicrobial Fatty Acids.mSphere · 2020Article
- Antimicrobial Prosthetic Surfaces in the Oral Cavity-A Perspective on Creative Approaches.Microorganisms · 2020Review
- Japanese subgingival microbiota in health vs disease and their roles in predicted functions associated with periodontitis.Odontology · 2020Article
- Antimicrobial Activity of Host-Derived Lipids.Antibiotics (Basel, Switzerland) · 2020Review
- Sphingosine is able to prevent and eliminate Staphylococcus epidermidis biofilm formation on different orthopedic implant materials in vitro.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Promise of Combining Antifungal Agents in Denture Adhesives to Fight Candida Species Infections.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2018Article
- Arachidonic acid and other unsaturated fatty acids and some of their metabolites function as endogenous antimicrobial molecules: A review.Journal of advanced research · 2018Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Oral mucosal and salivary lipids exhibit potent antimicrobial activity for a variety of Gram-positive and Gram-negative bacteria; however, little is known about their spectrum of antimicrobial activity or mechanisms of action against oral bacteria. In this study, we examine the activity of two fatty acids and three sphingoid bases against Porphyromonas gingivalis, an important colonizer of the oral cavity implicated in periodontitis. Minimal inhibitory concentrations, minimal bactericidal concentrations, and kill kinetics revealed variable, but potent, activity of oral mucosal and salivary lipids against P. gingivalis, indicating that lipid structure may be an important determinant in lipid mechanisms of activity against bacteria, although specific components of bacterial membranes are also likely important. Electron micrographs showed ultrastructural damage induced by sapienic acid and phytosphingosine and confirmed disruption of the bacterial plasma membrane. This information, coupled with the association of treatment lipids with P. gingivalis lipids revealed via thin layer chromatography, suggests that the plasma membrane is a likely target of lipid antibacterial activity. Utilizing a combination of two-dimensional in-gel electrophoresis and Western blot followed by mass spectroscopy and N-terminus degradation sequencing we also show that treatment with sapienic acid induces upregulation of a set of proteins comprising a unique P. gingivalis stress response, including proteins important in fatty acid biosynthesis, metabolism and energy production, protein processing, cell adhesion and virulence. Prophylactic or therapeutic lipid treatments may be beneficial for intervention of infection by supplementing the natural immune function of endogenous lipids on mucosal surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.