ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2014
Infantile exposure to lead and late-age cognitive decline: relevance to AD.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 93 citations in OpenAlex.
- Integrative bibliometric and transcriptomic analyses identify selenium-associated molecular signatures in the aging brain.Frontiers in aging neuroscience · 2026Article
- Prevalence and risk factors of elevated blood lead levels in 0-6-year-old children: a national cross-sectional study in China.Frontiers in public health · 2025Article
- The Effects of Pb on TNF-R1-RIPK1/RIPK3 Signaling Pathway in the Hippocampus of Mice.Neurochemical research · 2024Article
- Exposure to Lead in Drinking Water Causes Cognitive Impairment via an Alzheimer's Disease Gene-Dependent Mechanism in Adult Mice.Journal of Alzheimer's disease : JAD · 2024Article
- Metals in Alzheimer's Disease.Biomedicines · 2023Review
- Article
- Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum.Frontiers in public health · 2023Article
- Association between Heavy Metal Exposure and Parkinson's Disease: A Review of the Mechanisms Related to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2022Review
- Evolutionary Implications of Environmental Toxicant Exposure.Biomedicines · 2022Review
- From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms.Biology · 2022Article
- Half of US population exposed to adverse lead levels in early childhood.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Time-course miRNA alterations and SIRT1 inhibition triggered by adolescent lead exposure in mice.Toxicology research · 2021Article
- Environmental exposures and the etiopathogenesis of Alzheimer's disease: The potential role of BACE1 as a critical neurotoxic target.Journal of biochemical and molecular toxicology · 2021Review
- Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders.Journal of neurodevelopmental disorders · 2020Article
- Epigenetic influence of environmentally neurotoxic metals.Neurotoxicology · 2020Review
- Evaluation of chronic lead effects in the blood brain barrier system by DCE-CT.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020Article
- Low-level Lead Exposure Impairs Fronto-executive Functions: A Call to Update the DSM-5 with Lead Poisoning as a Neurodevelopmental Disorder.Psychology & neuroscience · 2020Article
- Persistent Effects on Cardiorespiratory and Nervous Systems Induced by Long-Term Lead Exposure: Results from a Longitudinal Study.Neurotoxicity research · 2020Article
- Association between blood lead level and subsequent Alzheimer's disease mortality.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Concentration-dependent effects of mercury and lead on Aβ42: possible implications for Alzheimer's disease.European biophysics journal : EBJ · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEarly-life lead (Pb) exposure induces overexpression of the amyloid beta precursor protein and its amyloid beta product in older rats and primates. We exposed rodents to Pb during different life span periods and examined cognitive function in old age and its impact on biomarkers associated with Alzheimer's disease (AD).
methodsMorris, Y, and the elevated plus mazes were used. Western blot, quantitative polymerase chain reaction (qPCR), and enzyme-linked immunosorbent assay were used to study the levels of AD biomarkers.
resultsCognitive impairment was observed in mice exposed as infants but not as adults. Overexpression of AD-related genes (amyloid beta precursor protein and β-site amyloid precursor protein cleaving enzyme 1) and their products, as well as their transcriptional regulator-specificity protein 1 (Sp1)-occurred only in older mice with developmental exposure to Pb.
conclusionsA window of vulnerability to Pb neurotoxicity exists in the developing brain that can influence AD pathogenesis and cognitive decline in old age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.