ArticleNutrients2013
Effects of dietary isoflavones from Puerariae radix on lipid and bone metabolism in ovariectomized rats.
Article in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
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- Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats.Nutrition research and practice · 2020Article
- Aqueous Extract ofFrontiers in pharmacology · 2020Article
- Improvement in Menopause-Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Enhancement of the antioxidant and hypolipidemic activities of Puerariae radix by fermentation withFood science and biotechnology · 2019Article
- Suppression Effect of Astaxanthin on Osteoclast Formation In Vitro and Bone Loss In Vivo.International journal of molecular sciences · 2018Article
- Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice.Experimental and therapeutic medicine · 2017Article
- Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells.Experimental and therapeutic medicine · 2017Article
- Article
- Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic Rats.PloS one · 2015Article
- The effect of Lycii Radicis Cortex extract on bone formation in vitro and in vivo.Molecules (Basel, Switzerland) · 2014Article
- A review on the traditional Chinese medicinal herbs and formulae with hypolipidemic effect.BioMed research international · 2014Review
- Antihyperlipidemic activity of chickpea sprouts supplementation in ovariectomy-induced dyslipidemia in rats.Journal of Ayurveda and integrative medicineArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puerariae radix, the dried root of Pueraria lobata Ohwi, is one of the earliest and most important edible crude herbs used for various medical purposes in oriental medicine. This study evaluated the metabolic effects of total isoflavones from P. lobata (PTIF) in ovariectomized (OVX) rats. The OVX rats were divided into four groups treated with distilled water, 17β-estradiol (E2 10 μg/kg, once daily, i.p.) and PTIF (30 and 100 mg/kg, once daily, p.o.) for eight weeks. The treatments with high-dose PTIF significantly decreased the bone mineral density (BMD) loss in the femur and inhibited the increase in body weight and lipoprotein levels compared to the OVX-control group without elevating the serum levels of the liver enzymes, aspartate aminotransferase (AST) and alanine transaminase (ALT). Furthermore, PTIF exhibits a hepatoprotective effect in OVX-induced hepatic steatosis, indicated with reduced hepatic lipid contents. Taken together, our findings suggest that PTIF may be useful for controlling lipid and bone metabolism, at least in OVX rats. Further research is necessary to determine whether PTIF will have the same effects in humans.
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