ReviewAmerican journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists2013
Description of outbreaks of health-care-associated infections related to compounding pharmacies, 2000-12.
Review in American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmaceutical Compounding: a History, Regulatory Overview, and Systematic Review of Compounding Errors.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021Pooled it
- The Misuse of Drug Compounding in the United States.The Journal of clinical and aesthetic dermatology · 2026Article
- Process-Related Incidents in Nuclear Medicine: A Four-Year Single-Center Retrospective Analysis to Support the Implementation of a Scenario-Based Radiopharmacy Training.Pharmacy (Basel, Switzerland) · 2026Article
- Extemporaneous Formulations for Pediatric Patients: Global Necessities, Challenges and Opportunities.Pharmaceutics · 2026Review
- Evaluating the efficacy of disinfecting products against Bacillus subtilis spore using an optimized method.Journal of industrial microbiology & biotechnology · 2026Article
- An Adequate Pharmaceutical Quality System for Personalized Preparation.Pharmaceutics · 2023Review
- Reducing the risk of non-sterility of aseptic handling in hospital pharmacies, part A: risk assessment.European journal of hospital pharmacy : science and practice · 2022Article
- Patient Safety Incidents Related to the Use of Parenteral Nutrition in All Patient Groups: A Systematic Scoping Review.Drug safety · 2022Article
- Retention of Sterile Compounding Knowledge Among Pharmacy Technicians.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2021Article
- Compounding Parenteral Products in Pediatric Wards-Effect of Environment and Aseptic Technique on Product Sterility.Healthcare (Basel, Switzerland) · 2021Article
- Implementation and validation of an in-house combined fluorescein/media-fill test to qualify radiopharmacy operators.EJNMMI radiopharmacy and chemistry · 2021Article
- Mining social media data to assess the risk of skin and soft tissue infections from allergen immunotherapy.The Journal of allergy and clinical immunology · 2019Article
- U.S. Compounding Pharmacy-Related Outbreaks, 2001-2013: Public Health and Patient Safety Lessons Learned.Journal of patient safety · 2018Review
- Seven cases of probable endotoxin poisoning related to contaminated glutathione infusions.Epidemiology and infection · 2018Article
- Emerging issues, challenges, and changing epidemiology of fungal disease outbreaks.The Lancet. Infectious diseases · 2017Review
- Update on medical and regulatory issues pertaining to compounded and FDA-approved drugs, including hormone therapy.Menopause (New York, N.Y.) · 2016Review
- Fungi associated with drug recalls and rare disease outbreaks.Journal of industrial microbiology & biotechnology · 2014Review
- Should Hospital Pharmacies That Are Not Fully Compliant with USP General Chapter <797> Standards Outsource, to the Fullest Extent Possible, the Preparation of Compounded Sterile Products to a Facility That Is Compliant?The Canadian journal of hospital pharmacy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposeOutbreaks of health-care-associated infections related to compounding pharmacies from 2000 through 2012 are described.
methodsPubMed and the websites for the Centers for Disease Control and Prevention and the Food and Drug Administration were searched to identify infectious outbreaks associated with compounding pharmacies outside the hospital setting between January 2000 and November 2012.
resultsBetween January 2000 and before the 2012 fungal meningitis outbreak, 11 outbreaks were identified, involving 207 infected patients and 17 deaths after exposure to contaminated compounded drugs. The 2012 meningitis outbreak had a similar mortality rate but increased these totals almost fivefold. Half of the outbreaks involved patients in more than one state. Three outbreaks involved ophthalmic drugs. The remaining outbreaks involved corticosteroids, heparin flush solutions, cardioplegia solution, i.v. magnesium sulfate, total parenteral nutrition, and fentanyl. The outbreaks were caused by pathogens commonly associated with health-care-associated infections, common skin commensals, and organisms that rarely cause infection. Morbidity was substantial, including vision loss. Half the outbreaks resulted in recall of all sterile drugs from the pharmacy due to systemic problems with sterile procedures.
conclusionBefore the nationwide 2012 fungal meningitis outbreak, drugs produced by compounding pharmacies were associated with 11 other smaller, but equally serious, outbreaks that occurred sporadically over the past 12 years. Lapses in sterile compounding procedures led to contamination of compounded drugs, exposure to patients, and a threat to public health in these outbreaks. Recognition and subsequent public health investigation were usually triggered by the occurrence of illness among multiple patients in a single health care setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.