ArticleThe Journal of biological chemistry2013
Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Complete remission of diabetes with a transient HDAC inhibitor and insulin in streptozotocin mice.Communications biology · 2023Article
- Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy.Experimental & molecular medicine · 2021Article
- Islet Regeneration: Endogenous and Exogenous Approaches.International journal of molecular sciences · 2021Review
- Article
- ERK5 plays an essential role in gestational beta-cell proliferation.Cell proliferation · 2018Article
- Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.Cell stem cell · 2018Article
- Article
- SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes.Diabetes · 2017Article
- GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor.Scientific reports · 2017Article
- Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice.The Journal of biological chemistry · 2017Article
- Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice.The Journal of biological chemistry · 2016Article
- Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas.Cell communication and signaling : CCS · 2016Article
- Centroacinar cells: At the center of pancreas regeneration.Developmental biology · 2016Review
- PNA lectin for purifying mouse acinar cells from the inflamed pancreas.Scientific reports · 2016Article
- Beta Cell Regeneration in Adult Mice: Controversy Over the Involvement of Stem Cells.Current stem cell research & therapy · 2016Review
- Concise Review: New Insights Into the Role of Macrophages in β-Cell Proliferation.Stem cells translational medicine · 2015Review
- Inhibition of progression of PanIN through antagonizing EGFR.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Impaired proliferation of pancreatic beta cells, by reduced placental growth factor in pre-eclampsia, as a cause for gestational diabetes mellitus.Cell proliferation · 2015Article
- Impact of Sox9 dosage and Hes1-mediated Notch signaling in controlling the plasticity of adult pancreatic duct cells in mice.Scientific reports · 2015Article
- Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
It remains controversial whether adult pancreatic ducts harbor facultative beta cell progenitors. Because neurogenin3 (Ngn3) is a key determinant of pancreatic endocrine cell neogenesis during embryogenesis, many studies have also relied upon Ngn3 expression as evidence of beta cell neogenesis in adults. Recently, however, Ngn3 as a marker of adult beta cell neogenesis has been called into question by reports of Ngn3 expression in fully-developed beta cells. Nevertheless, direct evidence as to whether Ngn3 activation in adult pancreatic duct cells may lead to duct-to-beta cell transdifferentiation is lacking. Here we studied two models of Ngn3 activation in adult pancreatic duct cells (low-dose alloxan treatment and pancreatic duct ligation) and lineage-traced Ngn3-activated duct cells by labeling them through intraductal infusion with a cell-tagging dye, CFDA-SE No dye-labeled beta cells were found during the follow-up in either model, suggesting that activation of Ngn3 in duct cells is not sufficient to direct their transdifferentiation into beta cells. Therefore, Ngn3 activation in duct cells is not a signature for adult beta cell neogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.