ArticleBritish journal of cancer1990
Alterations of oncogenes in metastatic tumours of human gastric carcinomas.
Article in British journal of cancer, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 62 citations in OpenAlex.
- Review
- Incorporation of a histone mutant with H3K56 site substitution perturbs the replication machinery in mouse embryonic stem cells.Journal of molecular cell biology · 2022Article
- Amplification of the c-erbB-2 (HER-2/neu) gene in gastric cancer cells. Detection by fluorescence in situ hybridization.The American journal of pathology · 1997Article
- Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis.British journal of cancer · 1995Article
- Frequent amplification of the cyclin E gene in human gastric carcinomas.Japanese journal of cancer research : Gann · 1995Article
- Chromosome 11q13 markers and D-type cyclins in breast cancer.Breast cancer research and treatment · 1995Review
- Analysis of c-erbB2 protein content of human glioma cells and tumor tissue.Journal of neuro-oncology · 1995Article
- Expression of c-erbB-2, c-myc, and c-ras oncoproteins, insulin-like growth factor receptor I, and epidermal growth factor receptor in ovarian carcinoma.Journal of clinical pathology · 1994Article
- DNA amplifications and elevated expression of proto-oncogene in addition to altered DNA ploidy in metastatic brain tumors.Clinical & experimental metastasis · 1994Article
- Expression of c-erbB-2 oncogene product in Barrett's adenocarcinoma: pathological and prognostic correlations.Journal of clinical pathology · 1994Article
- Reduced expression of nm23 is associated with metastasis of human gastric carcinomas.Japanese journal of cancer research : Gann · 1993Article
- Molecular mechanism of stomach carcinogenesis.Journal of cancer research and clinical oncology · 1993Article
- Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha.Journal of cancer research and clinical oncology · 1993Article
- Correlation of c-erbB-2 with invasion and metastasis in human gastric cancer.Gastroenterologia Japonica · 1992Article
- The effects of continuous exposure to epidermal growth factor on the spontaneous transformation of cultured rat liver epithelial cells.The American journal of pathology · 1992Article
- Induction of growth factor-receptor and metalloproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell line MKN-28.Japanese journal of cancer research : Gann · 1990Article
- Epidermal growth factor receptor expression correlates with histologic grade in resected esophageal adenocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether alterations in oncogenes are associated with tumour progression and metastasis, DNAs from 32 metastatic tumour samples of different sites in 12 autopsy cases of gastric carcinomas were analysed for alterations of ERBB, ERBB2, HST1, INT2 and LMYC genes by Southern blot hybridisation. DNAs from 89 primary gastric carcinomas including 69 advanced carcinomas and 20 early carcinomas were also examined. In primary tumours, no amplification was detected in early carcinomas, while amplification of ERBB and ERBB2 genes was detected in one (1.4%) and four (5.8%) out of 69 advanced carcinomas, respectively. In metastatic tumours, amplification of ERBB gene was detected in three metastatic tumours (9.4%), and all of them had allelic deletion of the LMYC gene. Regardless of histological type, amplification of ERBB2 gene was detected in 8 metastatic tumours (25.0%), out of which three tumours had coamplification of HST1 and INT2 genes. The incidence of ERBB2 amplification in metastatic tumours was significantly higher than that in primary tumours. These results indicate that multi-alterations in oncogenes might occur during tumour progression and metastasis of human gastric carcinomas.
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