ArticlePsychological medicine2014
The impact of parent socio-economic status on executive functioning and cortical morphology in individuals with schizophrenia and healthy controls.
Article in Psychological medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- The association between fronto-insular interaction and executive function during childhood and adolescence in a resting state fMRI study.Scientific reports · 2025Article
- Exposotypes in psychotic disorders.Scientific reports · 2025Article
- Relationship between cognition and age at onset of first-episode psychosis: comparative study between adolescents, young adults, and adults.European child & adolescent psychiatry · 2023Article
- Environmental Risk Factors and Cognitive Outcomes in Psychosis: Pre-, Perinatal, and Early Life Adversity.Current topics in behavioral neurosciences · 2023Review
- Current Socioeconomic Status Correlates With Brain Volumes in Healthy Children and Adolescents but Not in Children With Prenatal Alcohol Exposure.Frontiers in human neuroscience · 2020Article
- An approach to directly link ICA and seed-based functional connectivity: Application to schizophrenia.NeuroImage · 2018Article
- Connectivity-based whole brain dual parcellation by group ICA reveals tract structures and decreased connectivity in schizophrenia.Human brain mapping · 2015Article
- A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups.Schizophrenia bulletin · 2015Article
- Genetic influences on cognitive endophenotypes in schizophrenia.Schizophrenia research · 2014Article
- Executive function in patients with schizophrenia based on socio-occupational impairment: A cross-sectional study.Industrial psychiatry journalArticle
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundRelatively lower executive functioning is characteristic of individuals with schizophrenia. As low socio-economic status (SES) early in life (i.e. parent SES) has been linked with lower executive skills in healthy children, we hypothesized that parental SES (pSES) would be more strongly related to executive functioning in individuals with schizophrenia than in controls and have a greater impact on prefrontal cortical morphology.
methodHealthy controls (n = 125) and individuals with schizophrenia (n = 102) completed tests assessing executive functioning and intelligence. The groups were matched on pSES, which was evaluated with the Hollingshead-Redlich scale. A principal components analysis (PCA) was conducted on 10 variables from six executive tests, yielding three specific components (fluency, planning and response inhibition). Voxel-based morphometry (VBM) was used to evaluate effects of pSES on gray matter (GM) concentration.
resultsLower pSES was associated with lower scores across the three executive functioning components, and a significant group by pSES interaction was observed such that low pSES, in particular, affected individuals with schizophrenia. These effects remained significant when intellectual ability, education and self-SES (sSES) were added as covariates. VBM revealed that lower pSES was associated with reduced GM volume in several anterior brain regions, especially the superior frontal gyrus, in patients but not in controls.
conclusionsThese findings suggest that individuals with schizophrenia may be particularly vulnerable to the adverse impact of low pSES, in terms of both lower executive skills and reduced anterior GM volumes.
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