Evidence map›Paper›PMID 23866811›Full record

ArticleEpidemiology and infection2014

Use of virulence determinants and seropathotypes to distinguish high- and low-risk Escherichia coli O157 and non-O157 isolates from Europe.

M F Anjum, E Jones, V Morrison, R Tozzoli, S Morabito, I Toth, B Nagy, G Smith, A Aspan, E M Nielsen and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Characterization of Non-O157Microorganisms · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 8 countries.

M F AnjumDepartment of Bacteriology and Food Safety, Animal Health and Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK.
E JonesDepartment of Bacteriology and Food Safety, Animal Health and Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK.
V MorrisonDepartment of Bacteriology and Food Safety, Animal Health and Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK.
R TozzoliDepartment of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Viale Regina Elena Rome, Italy.
S MorabitoDepartment of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Viale Regina Elena Rome, Italy.
I TothVeterinary Medical Research Institute of the Hungarian Academy of Sciences, Budapest, Hungary.
B NagyVeterinary Medical Research Institute of the Hungarian Academy of Sciences, Budapest, Hungary.
G SmithHealth Protection Agency, London UK.
A AspanSVA, National Veterinary Institute, Uppsala, Sweden.
E M NielsenStatens Serum Institut, Department of Microbiological Surveillance and Research, Copenhagen, Denmark.
P FachANSES, French Agency for Food, Environmental and Occupational Health & Safety, Food Safety Laboratory, Maisons-Alfort, France.
S Herrera-LeónInstitute of Health Carlos III, National Center of Microbiology, Laboratory of Enterobacteraceae, Campylobacter and Vibrio, Majadahonda, Madrid, Spain.
M J WoodwardDepartment of Bacteriology and Food Safety, Animal Health and Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK.
R M LA RagioneDepartment of Bacteriology and Food Safety, Animal Health and Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK.
Animal and Plant Health Agency · GBIstituto Superiore di Sanità · ITAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail · FRHealth Protection Agency · MVHungarian Academy of Sciences · HUHUN-REN Veterinary Medical Research Institute · HUInstituto de Salud Carlos III · ESStatens Serum Institut · DKSwedish Veterinary Agency · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of 10 virulence genes was examined using polymerase chain reaction (PCR) in 365 European O157 and non-O157 Escherichia coli isolates associated with verotoxin production. Strain-specific PCR data were analysed using hierarchical clustering. The resulting dendrogram clearly separated O157 from non-O157 strains. The former clustered typical high-risk seropathotype (SPT) A strains from all regions, including Sweden and Spain, which were homogenous by Cramer's V statistic, and strains with less typical O157 features mostly from Hungary. The non-O157 strains divided into a high-risk SPTB harbouring O26, O111 and O103 strains, a group pathogenic to pigs, and a group with few virulence genes other than for verotoxin. The data demonstrate SPT designation and selected PCR separated verotoxigenic E. coli of high and low risk to humans; although more virulence genes or pulsed-field gel electrophoresis will need to be included to separate high-risk strains further for epidemiological tracing.

Indexed as

AnimalsCluster AnalysisEscherichia coli InfectionsEscherichia coli O157Escherichia coli ProteinsEuropeHumansPrevalenceSheepShiga-Toxigenic Escherichia coliSwineVirulenceEscherichia coli Proteins

Identifiers

PMID23866811
PMCPMC9161224
OpenAlexW1999459031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.