ReviewNature methods2013
From the connectome to brain function.
Review in Nature methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 291 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
291 citing papers in PubMed.
- Phylogeny of Cortical-Hippocampal Projections Reveals Selective Elimination of Input From Sensory Regions.Hippocampus · 2026Article
- Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience inNAR genomics and bioinformatics · 2026Article
- Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics.PLoS computational biology · 2026Article
- Signaling Connectomics: A Brain-wide Framework for Intercellular Communication.Experimental neurobiology · 2026Article
- Korean Red Ginseng Attenuates Dysfunctions and Modulates Inflammatory and Neuroplasticity Markers in the Harmaline-Induced Model of Essential Tremor.Brain and behavior · 2026Article
- Fast reconstruction of degenerate populations of conductance-based neuron models from spike times.PLoS computational biology · 2026Article
- Connectome simulations identify a central pattern generator circuit for fly walking.bioRxiv : the preprint server for biology · 2026Article
- Reductionism in Engram Neuroscience.The European journal of neuroscience · 2026Review
- Activity-dependent neuromodulation and calcium homeostasis cooperate to produce robust and modulable neuronal function.PLoS computational biology · 2026Article
- Feeding decision-making by a single neuron via disparate neurotransmitters.Nature communications · 2026Article
- Neuropeptides in control of left-right neural circuits.Trends in neurosciences · 2026Review
- Expression and RNAi characterization of neuropeptides underlying developmental regulation in the Colorado potato beetle.Frontiers in insect science · 2026Article
- Connectomes: a re-emerging hub dataset for neuroscience.Frontiers in neuroscience · 2026Review
- Bridging the translational gap in systems neuroscience: from circuit mechanisms to clinical therapeutics.Frontiers in pharmacology · 2026Review
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
- Prediction of neural activity in connectome-constrained recurrent networks.Nature neuroscience · 2025Article
- Method of the Year: EM connectomics.Nature methods · 2025Article
- Reconstruction of a connectome of single neurons in mouse brains by cross-validating multi-scale multi-modality data.Nature methods · 2025Article
- Behavioral age-detection in individuals reconstructs minute-scale developmental transcriptomics.bioRxiv : the preprint server for biology · 2025Article
- Molecular and functional diversity of the autonomic nervous system.Nature reviews. Neuroscience · 2025Review
231 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In this Historical Perspective, we ask what information is needed beyond connectivity diagrams to understand the function of nervous systems. Informed by invertebrate circuits whose connectivities are known, we highlight the importance of neuronal dynamics and neuromodulation, and the existence of parallel circuits. The vertebrate retina has these features in common with invertebrate circuits, suggesting that they are general across animals. Comparisons across these systems suggest approaches to study the functional organization of large circuits based on existing knowledge of small circuits.
Indexed as
Identifiers
23866325What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.