ArticleReproductive biology and endocrinology : RB&E2013
Unilateral or bilateral vagotomy induces ovulation in both ovaries of rats with polycystic ovarian syndrome.
Article in Reproductive biology and endocrinology : RB&E, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action.Comprehensive physiology · 2026Review
- Optimizing Non-Pharmacological Support for Perinatal Mental Health: A Bayesian Network Meta-Analysis of Intervention Effects by Pregnancy/Postpartum Stage.Current psychiatry reports · 2026Review
- Effects of different durations of high-intensity interval training or continuous training with/without metformin on lipid profile and malondialdehyde level in a rat model of polycystic ovary syndrome.Veterinary research forum : an international quarterly journal · 2026Article
- Adenomyosis and Adolescence: A Challenging Diagnosis and Complex Management.Diagnostics (Basel, Switzerland) · 2024Review
- Effect of physiotherapy on infertility treatment in polycystic ovary syndrome patients.Przeglad menopauzalny = Menopause review · 2024Article
- [Neuroendocrine features of the pathogenesis of polycystic ovary syndrome (literature review)].Problemy endokrinologii · 2023Article
- Organization of the Subdiaphragmatic Vagus Nerve and Its Connection with the Celiac Plexus and the Ovaries in the Female Rat.Brain sciences · 2023Article
- The role of the autonomic nervous system in polycystic ovary syndrome.Frontiers in endocrinology · 2023Review
- Neuroendocrine Determinants of Polycystic Ovary Syndrome.International journal of environmental research and public health · 2022Review
- Long Term Oral Administration of Oregano Essence Effectively Relieves Polycystic Ovarian Rats through Endocrine and Inflammatory Balance.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Participation of the Cholinergic System in the Development of Polycystic Ovary Syndrome.Molecules (Basel, Switzerland) · 2021Article
- In rats with estradiol valerate-induced polycystic ovary syndrome, the acute blockade of ovarian β-adrenoreceptors improve ovulation.Reproductive biology and endocrinology : RB&E · 2019Article
- Avoiding off-target effects in electrical stimulation of the cervical vagus nerve: Neuroanatomical tracing techniques to study fascicular anatomy of the vagus nerve.Journal of neuroscience methods · 2019Review
- Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides.Reproductive medicine and biology · 2019Review
- In Adult Rats With Polycystic Ovarian Syndrome, Unilateral or Bilateral Vagotomy Modifies the Noradrenergic Concentration in the Ovaries and the Celiac Superior Mesenteric Ganglia in Different Ways.Frontiers in physiology · 2019Article
- Pharmacological sympathetic denervation prevents the development of polycystic ovarian syndrome in rats injected with estradiol valerate.Reproductive biology and endocrinology : RB&E · 2018Article
- Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model.Iranian journal of basic medical sciences · 2018Article
- Polycystic ovary syndrome induced by exposure to testosterone propionate and effects of sympathectomy on the persistence of the syndrome.Reproductive biology and endocrinology : RB&E · 2017Article
- Phosphatidylinositide 3-kinase inhibition: A new potential target for the treatment of polycystic ovarian syndrome.Pharmaceutical biology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInjecting estradiol valerate (EV) to pre-pubertal or adult female rat results in effects similar to those observed in women with polycystic ovarian syndrome (PCOS). One of the mechanisms involved in PCOS development is the hyperactivity of the sympathetic nervous system. In EV-induced PCOS rats, the unilateral sectioning of the superior ovarian nerve (SON) restores ovulation of the innervated ovary. This suggests that, in addition to the sympathetic innervation, other neural mechanisms are involved in the development/maintenance of PCOS. The aims of present study were analyze if the vagus nerve is one of the neural pathways participating in PCOS development.
methodsTen-day old rats were injected with EV dissolved in corn oil. At 24-days of age sham-surgery, unilateral, or bilateral sectioning of the vagus nerve (vagotomy) was performed on these rats. The animals were sacrificed at 90-92 days of age, when they presented vaginal estrous preceded by a pro-estrus smear.
resultsIn EV-induced PCOS rats, unilateral or bilateral vagotomy restored ovulation in both ovaries. Follicle-stimulating hormone (FSH) levels in PCOS rats with unilateral or bilateral vagotomy were lower than in control rats.
conclusionsThis result suggests that in EV-induced PCOS rats the vagus nerve is a neural pathway participating in maintaining PCOS. The vagus nerve innervates the ovaries directly and indirectly through its synapsis in the celiac-superior-mesenteric ganglion, where the somas of neurons originating in the SON are located. Then, it is possible that vagotomy effects in EV-induced PCOS rats may be explained as a lack of communication between the central nervous system and the ovaries.
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