ArticleBMC ecology2013
Ecto- and endoparasite induce similar chemical and brain neurogenomic responses in the honey bee (Apis mellifera).
Article in BMC ecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
- Wake Up and Smell the Infected Bees: Volatile Cues ofEcology and evolution · 2026Article
- Infestation by Phorid Flies Disrupts Behavior and Immune Function in Honey Bees Monitored by Radio-frequency Identification.Neotropical entomology · 2026Article
- The Role ofVeterinary sciences · 2022Review
- The Beneficial Effect of Pollen on Varroa Infested Bees Depends on Its Influence on Behavioral Maturation Genes.Frontiers in insect science · 2022Article
- Inflammatory bowel disease-associatedFrontiers in cellular and infection microbiology · 2022Article
- Nosema apis and N. ceranae Infection in Honey bees: A Model for Host-Pathogen Interactions in Insects.Experientia supplementum (2012) · 2022Article
- Cuticular Hydrocarbon Profile of Parasitic Beetles,Insects · 2021Article
- Increased alarm pheromone component is associated withRoyal Society open science · 2021Article
- Effects of Synthetic Acaricides andVeterinary sciences · 2020Article
- Host behaviour alteration by its parasite: from brain gene expression to functional test.Proceedings. Biological sciences · 2020Article
- Selection and hybridization shaped the rapid spread of African honey bee ancestry in the Americas.PLoS genetics · 2020Article
- Honey bee virus causes context-dependent changes in host social behavior.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Sub-lethal effects of the consumption of Eupatorium buniifolium essential oil in honeybees.PloS one · 2020Article
- Interactions Between Thiamethoxam andFrontiers in microbiology · 2020Article
- Pollen Alters Amino Acid Levels in the Honey Bee Brain and This Relationship Changes With Age and Parasitic Stress.Frontiers in neuroscience · 2020Article
- Review
- Natural biocide disrupts nestmate recognition in honeybees.Scientific reports · 2019Article
- What are the Mechanisms Behind a Parasite-Induced Decline in Nestmate Recognition in Ants?Journal of chemical ecology · 2017Article
- Unity in defence: honeybee workers exhibit conserved molecular responses to diverse pathogens.BMC genomics · 2017Article
- Brain metabolomic profiling of eastern honey bee (Apis cerana) infested with the mite Varroa destructor.PloS one · 2017Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExclusion from a social group is an effective way to avoid parasite transmission. This type of social removal has also been proposed as a form of collective defense, or social immunity, in eusocial insect groups. If parasitic modification of host behavior is widespread in social insects, the underlying physiological and neuronal mechanisms remain to be investigated. We studied this phenomenon in honey bees parasitized by the mite Varroa destructor or microsporidia Nosema ceranae, which make bees leave the hive precociously. We characterized the chemical, behavioral and neurogenomic changes in parasitized bees, and compared the effects of both parasites.
resultsAnalysis of cuticular hydrocarbon (CHC) profiles by gas chromatography coupled with mass spectrophotometry (GC-MS) showed changes in honey bees parasitized by either Nosema ceranae or Varroa destructor after 5 days of infestation. Levels of 10-HDA, an antiseptic important for social immunity, did not change in response to parasitism. Behavioral analysis of N. ceranae- or V. destructor- parasitized bees revealed no significant differences in their behavioral acts or social interactions with nestmates. Digital gene expression (DGE) analysis of parasitized honey bee brains demonstrated that, despite the difference in developmental stage at which the bee is parasitized, Nosema and Varroa-infested bees shared more gene changes with each other than with honey bee brain expression gene sets for forager or nurse castes.
conclusionsParasitism by Nosema or Varroa induces changes to both the CHC profiles on the surface of the bee and transcriptomic profiles in the brain, but within the social context of the hive, does not result in observable effects on her behavior or behavior towards her. While parasitized bees are reported to leave the hive as foragers, their brain transcription profiles suggest that their behavior is not driven by the same molecular pathways that induce foraging behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.