ArticleBMC microbiology2013
Conservation of the genes for HC-toxin biosynthesis in Alternaria jesenskae.
Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Apicidin is a key virulence determinant of Fusarium asiaticum in wheat-rice cropping systems.Science China. Life sciences · 2026Article
- Genome mining reveals the distribution of biosynthetic gene clusters in Alternaria and related fungal taxa within the family Pleosporaceae.BMC genomics · 2025Article
- Genomic Based Analysis of the Biocontrol SpeciesJournal of fungi (Basel, Switzerland) · 2023Article
- Knowledge-guided data mining on the standardized architecture of NRPS: Subtypes, novel motifs, and sequence entanglements.PLoS computational biology · 2023Article
- Differential Regulation and Production of Secondary Metabolites among Isolates of the Fungal Wheat Pathogen Zymoseptoria tritici.Applied and environmental microbiology · 2022Article
- Recent Advances inJournal of fungi (Basel, Switzerland) · 2022Review
- Apicidin biosynthesis is linked to accessory chromosomes in Fusarium poae isolates.BMC genomics · 2021Article
- Genome sequence of Monilinia vaccinii-corymbosi sheds light on mummy berry disease infection of blueberry and mating type.G3 (Bethesda, Md.) · 2021Article
- Whole Genome Sequence ofFrontiers in microbiology · 2021Article
- Time-Course RNAseq RevealsFrontiers in microbiology · 2020Article
- Comparative genomics of Alternaria species provides insights into the pathogenic lifestyle of Alternaria brassicae - a pathogen of the Brassicaceae family.BMC genomics · 2019Article
- Network analysis exposes core functions in major lifestyles of fungal and oomycete plant pathogens.BMC genomics · 2019Article
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- Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
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- Secondary metabolites in fungus-plant interactions.Frontiers in plant science · 2015Review
- A chemical ecogenomics approach to understand the roles of secondary metabolites in fungal cereal pathogens.Frontiers in microbiology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHC-toxin, a cyclic tetrapeptide, is a virulence determinant for the plant pathogenic fungus Cochliobolus carbonum. It was recently discovered that another fungus, Alternaria jesenskae, also produces HC-toxin.
resultsThe major genes (collectively known as AjTOX2) involved in the biosynthesis of HC-toxin were identified from A. jesenskae by genomic sequencing. The encoded orthologous proteins share 75-85% amino acid identity, and the genes for HC-toxin biosynthesis are duplicated in both fungi. The genomic organization of the genes in the two fungi show a similar but not identical partial clustering arrangement. A set of representative housekeeping proteins show a similar high level of amino acid identity between C. carbonum and A. jesenskae, which is consistent with the close relatedness of these two genera within the family Pleosporaceae (Dothideomycetes).
conclusionsThis is the first report that the plant virulence factor HC-toxin is made by an organism other than C. carbonum. The genes may have moved by horizontal transfer between the two species, but it cannot be excluded that they were present in a common ancestor and lost from other species of Alternaria and Cochliobolus.
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