ArticleBMC genomics2013
Defining natural species of bacteria: clear-cut genomic boundaries revealed by a turning point in nucleotide sequence divergence.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Article
- One species, many faces: The underappreciated importance of strain diversity.PLoS pathogens · 2024Article
- Article
- Considerations on the Identity and Diversity of Organisms Affiliated withMicroorganisms · 2021Article
- E. coli diversity: low in colorectal cancer.BMC medical genomics · 2020Article
- Genetic boundaries delineate the potential human pathogen Salmonella bongori into discrete lineages: divergence and speciation.BMC genomics · 2019Article
- Distinct evolutionary origins of common multi-drug resistance phenotypes in Salmonella typhimurium DT104: a convergent process for adaptation under stress.Molecular genetics and genomics : MGG · 2019Article
- Differential degeneration of the ACTAGT sequence among Salmonella: a reflection of distinct nucleotide amelioration patterns during bacterial divergence.Scientific reports · 2017Article
- Comparative Genomics Analysis of Streptomyces Species Reveals Their Adaptation to the Marine Environment and Their Diversity at the Genomic Level.Frontiers in microbiology · 2016Article
- Complete genome sequence of Salmonella enterica subspecies arizonae str. RKS2983.Standards in genomic sciences · 2015Article
- Differential efficiency in exogenous DNA acquisition among closely related Salmonella strains: implications in bacterial speciation.BMC microbiology · 2014Article
- CTAG-containing cleavage site profiling to delineate Salmonella into natural clusters.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacteria are currently classified into arbitrary species, but whether they actually exist as discrete natural species was unclear. To reveal genomic features that may unambiguously group bacteria into discrete genetic clusters, we carried out systematic genomic comparisons among representative bacteria.
resultsWe found that bacteria of Salmonella formed tight phylogenetic clusters separated by various genetic distances: whereas over 90% of the approximately four thousand shared genes had completely identical sequences among strains of the same lineage, the percentages dropped sharply to below 50% across the lineages, demonstrating the existence of clear-cut genetic boundaries by a steep turning point in nucleotide sequence divergence. Recombination assays supported the genetic boundary hypothesis, suggesting that genetic barriers had been formed between bacteria of even very closely related lineages. We found similar situations in bacteria of Yersinia and Staphylococcus.
conclusionsBacteria are genetically isolated into discrete clusters equivalent to natural species.
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